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【medical-news】2008年肝细胞癌治疗新进展--已经全
还有，怎样充分利用？毕竟这是大家的心血！ 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Novel advancements in the management of hepatocellular carcinoma in 2008☆肝细胞癌2008年的治疗新进展
Josep M. Llovet12, Jordi Bruix1
published online 13 February 2008.
New advancements have emerged in the field of hepatocellular carcinoma (HCC) in recent years. 近些年在肝细胞癌领域出现了很多新的进展。
There has been a switch in the type of presentation of HCC in developed countries, with a clear increase of tumors <2cm in diameter as a result of the wide implementation of surveillance programs.
目前在发达国家中，随着检查手段的广泛普及，肝细胞癌的类型发生了转变，直径小于2cm的肿瘤较前明显增加。
Non-invasive radiological techniques have been developed and validated for the diagnosis of small and tiny HCCs. 非侵入性的放射学技术已被发明并确定对诊断小型和微小型肝细胞癌是有效的。
Simultaneously, diagnostic criteria based on molecular profiling of early tumors have been proposed. 同时，根据分子描出提出了早期肿瘤的诊断标准。
The current clinical classification of HCC divides patients into 5 stages with a specific treatment-oriented schedule. 根据目前通用的临床分类可以把肝细胞癌患者分成5期，每一期都有一个特定的针对治疗方案。
There is no established molecular classification of HCC, although preliminary proposals have already been published. 尽管初步的提议已经公布，但是至今肝细胞癌仍然没有一个确定的分子分类。
Advancements in the treatment arena have come from well designed trials. 设计严谨的临床试验报道了肝细胞癌的治疗进展。
Radiofrequency ablation is currently consolidated as providing better local control of the disease compared with percutaneous ethanol injection. 目前已经证明射频消融是比经皮酒精注射更好的局部治疗方法。
New devices are available to improve the anti-tumoral efficacy of conventional chemoembolization. 而且新的设备可以改善传统的化疗栓塞的抗肿瘤效应。Sorafenib, a multikinase inhibitor, has shown survival benefits in patients at advanced stages of the disease. 索拉菲尼是一种多酶抑制药，而且已经证明可以提高进展期病人的生存率。
This advancement represents a breakthrough in the management of this complex disease, and proves that molecular targeted therapies can be effective in this otherwise chemo-resistant tumor. 这方面的进展代表着在这个复杂疾病处理上的一个突破。肝癌具有多药耐药性，但研究证明这种分子靶向对其治疗是有效的。
Consequently, sorafenib will become the standard of care in advanced cases, and the control arm for future trials. 同时，索拉菲尼将会是早期病例的标准治疗方法和未来试验的对照药。
Now, the research effort faces other areas of unmet need, such as the adjuvant setting of resection/local ablation and combination therapies.
现在，这个研究成果正面临一些其他未曾涉及的领域，比如切除术/局部消融和联合治疗的辅助治疗。 很好的文章。学习了，希望早日攻克癌症。 很高兴有战友专注，特提供全文衔接：http://www.jhep-elsevier.com/article/S0168-8278(08)00078-0/fulltext 学习了！ molecular targeted therapies
是不是译为:"分子靶向治疗"更为合适哦! 谢谢！ local ablation 局部消融
advanced cases 进展期病例
molecular targeted therapies can be effective in this otherwise chemo-resistant tumor
肝癌具有多药耐药性，但研究证明这种分子靶向对其治疗
Advancements in the treatment arena have come from well designed trials
设计严谨的临床试验报道了肝细胞癌的治疗进展
........ Josep M. Llovet, Jordi Bruix 两位肝胆界的牛人
附上全文（两个附件 请大家将其整合），大家共同学习
ents in the management of hepatocellular.part1.rar (200.0k) 附件2
ents in the management of hepatocellular.part2.rar (168.82k) 欢迎大家对全文内容进行深度讨论、学习！ 肝癌的治疗是很令人失望的........ 这么多战友关注，个人认为有必要翻译一下！
PDF文件18页，希望有战友参与翻译，奉献给DXYer！
可以留邮箱或者PM我，我可以发给大家！ 全文好长哦，可惜自己的英文不够好，正在慢慢看。 Article Outline
• Abstract
• 1. Introduction
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作者:admin@医学,生命科学 2011-02-24 05:14
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