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【medical-news】研究发现激素替代可以提高生活质
WASHINGTON (Reuters) - Hormone replacement therapy can improve the quality of a woman's life, easing the distress of hot flashes, sleep disturbances and restoring lost sexual functioning, researchers reported on Thursday.
About three out of four women who suffered night sweats and hot flushes said the symptoms vanished after a year of HRT use, the researchers reported in the British Medical Journal.
Half the women, aged 50 to 69 when the study started, received Wyeth's Prempro, a combined estrogen replacement pill, while the rest got a placebo.
"Combined HRT improves sleep, aches and pains, and sexual functioning," wrote the researchers, led by Amanda Welton of Britain's Medical Research Council and Alastair MacLennan of the University of Adelaide in Australia.
"These gains can now be factored in to a woman's choice to use combined HRT. This benefit must be weighed against the overall short and long-term risks, which must be individualized for women based on years since menopause, medical history, and chosen regimen."
HRT was popular until 2002 when a Women's Health Initiative study showed it could raise the risk of breast and ovarian cancer, stroke and other serious conditions.
The findings spurred millions of women to abandon HRT and weighed down the shares of hormone therapy makers like Wyeth.
The "women's international study of long duration oestrogen after the menopause" or WISDOM was set up to evaluate the long-term benefits and risks of HRT, but was stopped early in 2002 after the Women's Health Initiative findings.
Welton's team questioned more than 2,000 of the women after a year on HRT to see what the benefits or drawbacks might be.
"After one year small but significant improvements were observed in three of nine components of the women's health questionnaire for those taking combined HRT compared with those taking placebo: vasomotor symptoms, sexual functioning, and sleep problems," they wrote.
"No significant differences in other menopausal symptoms, depression, or overall quality of life were observed at one year."
Like the women in the Women's Health Initiative study, many of the women in the WISDOM study were well past menopause when they started HRT. Their average age was nearly 64, more than a dozen years since they entered menopause.
Many experts have said HRT is probably safer for women just beginning menopause, which starts at about an average age of 51 but usually begins causing symptoms years earlier.
The British, Australian and New Zealand researchers said health issues do not have to be life-or-death matters to be important to a patient's life.
"In many circumstances, quality of survival is as important as quantity," they wrote.
Most doctors now advise that women use the lowest dose possible of HRT for the shortest possible amount of time to manage the symptoms of menopause.
"The findings are unlikely to impact significantly on the current management of menopausal symptoms, very effectively and safely accomplished with currently used doses of HRT," said Henry Burger of Australia's Monash University, a former president of the International Menopause Society.
http://www.reuters.com/article/healthNews/idUSN2145746220080821 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Hormone replacement can improve life quality: study
研究发现激素替代疗法可以改善生活质量
WASHINGTON (Reuters) - Hormone replacement therapy can improve the quality of a woman's life, easing the distress of hot flashes, sleep disturbances and restoring lost sexual functioning, researchers reported on Thursday.
华盛顿（路透社）-周二，研究者报道激素替代疗法可以改善女性生活质量，减轻脸潮红感、较少失眠并且恢复丧失的性功能。
About three out of four women who suffered night sweats and hot flushes said the symptoms vanished after a year of HRT use, the researchers reported in the British Medical Journal.
在《英国医学杂志》中，研究者报道，3/4的伴有夜间盗汗和脸潮红的妇女称在使用HRT一年后，这些症状消失。
Half the women, aged 50 to 69 when the study started, received Wyeth's Prempro, a combined estrogen replacement pill, while the rest got a placebo.
从研究开始，一半年龄在50-69岁的女性服用惠氏Prempro（一种符合雌激素替代片），另一半女性服用安慰剂。
"Combined HRT improves sleep, aches and pains, and sexual functioning," wrote the researchers, led by Amanda Welton of Britain's Medical Research Council and Alastair MacLennan of the University of Adelaide in Australia.
澳大利亚学者写到，“复合HRT改善睡眠，疼痛和性功能。”
"These gains can now be factored in to a woman's choice to use combined HRT. This benefit must be weighed against the overall short and long-term risks, which must be individualized for women based on years since menopause, medical history, and chosen regimen."
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作者:admin@医学,生命科学 2011-02-05 17:14
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