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【bio-news】肥胖基因使人难获＂饱感＂
Published: Monday, 28-Jul-2008
A study involving more than 3,000 children in Britain has found those with a gene linked to obesity find it harder than others to tell when they are full.
The researchers from University College and the Institute of Psychiatry, at King's College, in London, wanted to learn more about the way the FTO gene on human chromosome 16, which has been linked to obesity, works and whether it had an impact on the ability to burn calories or appetite.
The FTO gene is the first common gene to be linked to obesity in Caucasian populations and the researchers found those with copies of the gene's risky variant were less likely to have their appetite "switched off" when they should be full.
Previous research has indicated that adults with two copies of the higher risk version of the gene are on average 3kg heavier, and those with a single copy are on average 1.5kg heavier, than those without the gene.
The researchers tested whether the children age 8 and 11 carrying the higher risk gene variation had an altered appetite through height, weight and waist circumference measurements, and gave parents a questionnaire which asked about their child's eating habits.
They found that such children tended to overeat and to struggle to recognise when they were full and the effect of the gene on appetite was the same regardless of age, sex, socio-economic background and body mass index.
Lead researcher Professor Jane Wardle says it is not simply the case that people who carry the risky variant of this gene automatically become overweight, but they are more susceptible to overeating, which makes them significantly more vulnerable to the modern environment which is confronting with large portion sizes and limitless opportunities to eat.
Professor Wardle says the effect of the gene in isolation was relatively small and it was likely that many genes contributed to obesity and appetite, each making a small contribution, but together creating a substantial effect.
The researchers believe that the results help to uncover how genes can make us fat.
The study is published in the Journal of Clinical Endocrinology & Metabolism.
http://www.news-medical.net/?id=40289 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 A study involving more than 3,000 children in Britain has found those with a gene linked to obesity find it harder than others to tell when they are full.
The researchers from University College and the Institute of Psychiatry, at King's College, in London, wanted to learn more about the way the FTO gene on human chromosome 16, which has been linked to obesity, works and whether it had an impact on the ability to burn calories or appetite.
英国一项覆盖了3000名以上儿童的研究发现，那些具有一种肥胖相关基因的孩子比别人更难觉察饱感。来自一些大学、学院和伦敦国王学院精神病协会的研究人员希望能够进一步阐明与肥胖相关的、位于人类16号染色体的FTO基因的作用机制及其是否在燃烧卡路里和改变食欲方面具有积极作用。
The FTO gene is the first common gene to be linked to obesity in Caucasian populations and the researchers found those with copies of the gene's risky variant were less likely to have their appetite "switched off" when they should be full.
FTO基因是白种人最常见的与肥胖有关的基因，研究者发现具有该基因危险变异型的人群在已经饱食之后更难于让自己的食欲减低。
Previous research has indicated that adults with two copies of the higher risk version of the gene are on average 3kg heavier, and those with a single copy are on average 1.5kg heavier, than those without the gene.
前期研究已经显示，与没有携带该基因的人群相比，具有两份该基因高危险变异型拷贝的成年人体重较之高出3kg，具有一份该基因的成年人体重较之高出1.5kg。
The researchers tested whether the children age 8 and 11 carrying the higher risk gene variation had an altered appetite through height, weight and waist circumference measurements, and gave parents a questionnaire which asked about their child's eating habits.
研究人员还通过测量身高、体重、腰围来调查具有该基因高危变异型的8岁和11岁的孩子们的食欲差异，并对父母们进行了问卷调查，已进一步了解孩子们的饮食习惯。
They found that such children tended to overeat and to struggle to recognise when they were full and the effect of the gene on appetite was the same regardless of age, sex, socio-economic background and body mass index.
他们发现这些孩子有过度饮食的倾向，很难意识到他们已经吃饱，而且此基因在影响食欲方面的作用是一致的，与年龄、性别、社会经济背景和体重指数等无关。
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作者:admin@医学,生命科学 2011-08-22 06:39
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