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【bio-news】诺贝尔获奖成果Nature撤稿
http://www.nature.com/news/2008/080305/full/452013a.html
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Nobel prizewinner's paper retracted
Failure to reproduce results deals blow to work on olfactory networks.
Heidi Ledford
A paper in Nature co-authored by Nobel prizewinning scientist Linda Buck has been retracted after the researchers were unable to reproduce the results. The authors now report that they have found “inconsistencies” between the original data and the data published in 2001.
The retracted paper (Z. Zou, L. F. Horowitz, J. -P. Montmayeur, S. Snapper and L. B. Buck Nature 414, 173–179 ; 2001) describes tracing individual neural pathways from scent receptors in the nose through to the brain's olfactory cortex. Researchers in Buck's lab, then at Harvard Medical School in Boston, Massachusetts, produced transgenic mice that expressed a plant protein in neurons that have a specific odour receptor. The plant protein can travel across the junctions between neurons, allowing researchers to map neuronal networks by pinpointing the protein's location.
But researchers in Buck's lab, now at the Fred Hutchinson Cancer Research Center in Seattle, Washington, have since been unable to reproduce the original results. A subsequent review cast doubt on the validity of the published data. “There were inconsistencies in the data that were in figures contributed to the paper by the first author compared to the original data,” says Buck. “I would say that we have totally lost confidence in the conclusions of that paper.”
A synopsis of author contributions, published together with the retraction (see page 120 ), lists co-first-author Zhihua Zou as solely responsible for providing data and figures for the paper. Zou, now a researcher at the University of Texas Medical Branch in Galveston, did not respond to Nature's requests for comment. Lisa Horowitz, who shared first authorship with Zou and continues to work in Buck's lab, was credited only with providing reagents and designing experiments.
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Harvard Medical School has formed an ad hoc committee to review the retraction, and Buck has asked the Fred Hutchinson Cancer Research Center to review two later publications on which Zou was the lead author. “It's disappointing of course,” says Buck. “The important thing is to correct the literature.” The retracted paper has been cited 138 times, according to Thomson Scientific's ISI Web of Knowledge.
But the retraction will probably have only a minor effect on the field, says olfactory-neuron researcher Hitoshi Sakano of the University of Tokyo, Japan. Other researchers have corroborated some of the paper's results using other techniques, he notes. Neuroscientist Gilles Laurent of the California Institute of Technology in Pasadena, whose work on insect olfactory networks has occasionally conflicted with the results reported by Buck's lab, says that this has not hindered his research. “These questions are sufficiently complex and require such large amounts of data at high resolution that I have never considered them convincingly resolved in any system,” he says. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Published online 5 March 2008 | Nature 452, 13 (2008) | doi:10.1038/452013a
http://www.nature.com/news/2008/080305/full/452013a.html
News
新闻
Nobel prizewinner's paper retracted
Failure to reproduce results deals blow to work on olfactory networks.
诺贝尔奖获得者的文章撤回
未能重复出结果，对研究嗅觉网络的工作有破坏作用
Heidi Ledford
A paper in Nature co-authored by Nobel prizewinning scientist Linda Buck has been retracted after the researchers were unable to reproduce the results. The authors now report that they have found “inconsistencies” between the original data and the data published in 2001.
在Nature上面的一篇由诺贝尔奖获得者Linda Buck与人共同署名的文章已被撤回，原因是研究者不能重复出文章所述结果。文章作者现在汇报他们发现原始数据与2001年出版的数据之间有矛盾。
The retracted paper (Z. Zou, L. F. Horowitz, J. -P. Montmayeur, S. Snapper and L. B. Buck Nature 414, 173–179 ; 2001) describes tracing individual neural pathways from scent receptors in the nose through to the brain's olfactory cortex. Researchers in Buck's lab, then at Harvard Medical School in Boston, Massachusetts, produced transgenic mice that expressed a plant protein in neurons that have a specific odour receptor. The plant protein can travel across the junctions between neurons, allowing researchers to map neuronal networks by pinpointing the protein's location.
被撤回的文章(Z. Zou, L. F. Horowitz, J. -P. Montmayeur, S. Snapper and L. B. Buck Nature 414, 173–179 ; 2001)介绍的是追踪通过鼻子的嗅觉受体到大脑的嗅觉皮质的个体神经通路。在马萨诸塞州波士顿的哈佛医学院的Buck实验室的研究者们制造了一批转基因小鼠，这些小鼠的特点是在有特定气味受体的神经元上面可以表达植物蛋白质。这种植物蛋白质可以通过神经元之间的连接，这就使得研究者们可以通过精确定位蛋白质的位置来描绘出神经元的网络图。
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作者:admin@医学,生命科学 2011-02-19 17:14
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