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《Science》：癌症转移可能比预想的早（附全文链
癌症转移是最终引起大多数癌症患者死亡的疾病进程。学术界一直认为转移是癌症进展中的一个晚期事件，即在原发肿瘤细胞积累了一系列的基因变更之后才启动了癌症基因。然而，美国学者Katrina Podsypanina及其同事开展的动物实验结果提示，肿瘤的转移可能肇端于疾病早期。它们在器官的转移处保持休眠状态，直到癌症基因被启动时变身为癌细胞。
研究人员给小鼠注射了通过实验处理的正常乳腺细胞，使其在注射后的不同时间，激活其中的某些癌症基因（或称肿瘤基因）。研究发现，这些正常的乳腺细胞能够通过血液循环行进到肺部，并可在那里存活长达16个星期，但不表达任何的肿瘤基因。这些细胞在肿瘤基因被激活前，在肺中不会活跃生长。Katrina Podsypanina提出，对癌症转移过程的每一步骤进行调查，包括那些正常细胞的转移，可能会使科学家找到摧毁引起癌症转移细胞的新策略。（来源：健康报 王雪飞）
（《科学》（Science），DOI: 10.1126/science.1161621，Katrina Podsypanina，Harold Varmus）
http://www.sciencenet.cn/htmlpaper/20088291358165533318.html http://www.sciencemag.org/cgi/content/abstract/1161621v1
全文链接，不知道哪位战友可以下载啊？
多谢！ Rethinking cancer metastasis
The spread of cancer to new sites in the body -- the process that is ultimately responsible for most cancer deaths -- may happen earlier in the disease process than was previously thought, new research on mice suggests, researchers report in the Aug. 28 issue of Science. This discovery suggests an explanation for why some breast cancers, for example, metastasize long after the initial tumor has been treated. Because cancer metastasis involves multiple steps -- the cells must be equipped to survive the trip in the bloodstream and initiate malignant growth in their new environment -- researchers have traditionally considered it to be a late event in cancer progression that occurs after primary tumor cells have racked up a series of genetic alterations that switch on cancer genes. The new results suggest that metastatic disease might instead arise from normal cells that spread relatively early in the disease and remain dormant at the new organ site until cancer genes are switched on.
Katrina Podsypanina and colleagues injected mice with normal mammary cells that had been experimentally manipulated in a way that allowed the researchers to turn on certain cancer genes, or "oncogenes," at various times after injection. The researchers found that the normal mammary cells were capable of traveling in the bloodstream to the lungs and surviving there for up to 16 weeks without expressing any oncogenes. The cells did not begin growing aggressively in the lungs until the oncogenes had been turned on. Examining each step of the process by which cancer metastasizes, including those involving normal cells, might allow scientists to identify new strategies for destroying the cells responsible for the disease's spread through the body, the authors suggest. 想看全文，大家帮帮忙啊，多谢！ Full text:
http://louyinjun2.ys168.com/
in document of paper: Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung 非常感谢！
lwjssry wrote:
非常感谢！
谢谢yinjunlou 谢谢yinjunlou 为什么总有人为帖子设置权限啊？ 是啊
真是的
什么都搞什么特权
我们新人怎么办啊 全文Seeding/ www.sciencexpress.org / 28 August 2008 / Page 1 / 10.1126/science.1161621
Acquisition of metastatic ability by tumor cells is
considered a late event in the evolution of malignant
tumors. Here we report that untransformed mouse
mammary cells, engineered to express inducible oncogenic
transgenes: MYC and KrasD12, or polyoma middle T, and
introduced into the systemic circulation of a mouse, can
bypass transformation at the primary site and develop
into metastatic pulmonary lesions upon immediate or
delayed oncogene induction. Therefore, previously
untransformed mammary cells may establish residence in
the lung once they have entered the bloodstream, and may阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-11-29 17:13
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