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【medical-news】促红细胞生成素对周围神经末梢损
Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.
Background: Erythropoietin is a naturally occurring hormone with multiple effects on a number of different cell types. Recent data have suggested neuroprotective and perhaps even neurotrophic roles for erythropoietin. We hypothesized that these functional effects could be demonstrable in standard models of peripheral nerve injury.
Methods: Experiments were undertaken to evaluate the effect of erythropoietin on the previously reported standard course of healing of sciatic injuries in mice. The injury groups included mice that were subjected to (1) sham surgery, (2) a calibrated sciatic crush injury, (3) transection of the sciatic nerve followed by epineural repair, or (4) a transection followed by burial of the proximal stump in the adjacent muscle tissue (neurectomy). Either erythropoietin or saline solution was administered to the mice in each of these experimental groups twenty-four hours preinjury, immediately after surgical creation of the injury, twenty-four hours postinjury, or one week postinjury. All mice were evaluated on the basis of the published model for recovery of sciatic nerve motor function by measuring footprint parameters at specific times after the injury. Immunohistochemistry was also performed to assess the erythropoietin-receptor expression profile at the site of injury.
Results: In general, the mice treated with erythropoietin recovered sciatic nerve motor function significantly faster than did the untreated controls. This conclusion was based on a sciatic function index that was 60% better in the erythropoietin-treated mice at seven days postinjury (p < 0.05). Although the group that had been given the erythropoietin immediately postinjury showed the best enhancement of recovery, the timing of the administration of the drug was not critical. Histological analysis demonstrated enhanced erythropoietin-receptor positivity in the nerves that recovered fastest, suggesting that accelerated healing correlates with expression of the receptor in nerve tissue.
Conclusions: Erythropoietin treatment of an acute sciatic nerve crush injury leads to an effect consistent with functional neuroprotection. This protective effect may have clinical relevance, especially since it was detectable even when erythropoietin had been administered up to one week after injury.
Clinical Relevance: Erythropoietin may represent a safe therapeutic agent to enhance nerve recovery in humans either after or before "nerve-at-risk" procedures as well as a useful adjunct to treatment of peripheral nerve crush injuries.
本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury
促红细胞生成素对周围神经末梢损伤后功能恢复的促进作用
Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.
声明：作者从未接受任何外来筹资或捐款用于支持此项研究或准备工作。不论是作者自身或是其直系亲属都没有接受过任何报酬或其他收益，亦没有承诺为任何商业实体提供收益。无任何商业实体支付过或准备支付任何好处给研究基金会，公司，中心，临床实践机构或其他慈善，非赢利组织。没有任何作者及其直系亲属与之相关或依附。
Background: Erythropoietin is a naturally occurring hormone with multiple effects on a number of different cell types. Recent data have suggested neuroprotective and perhaps even neurotrophic roles for erythropoietin. We hypothesized that these functional effects could be demonstrable in standard models of peripheral nerve injury.
背景资料：促红细胞生成素是一种天然存在的激素，对能对各种不同的细胞发挥多种作用。最新资料认为促红细胞生成素在神经保护和神经再生方面亦发挥作用。我们假定这些功能可在末梢神经标准化模型下得以论证。
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作者:admin@医学,生命科学 2010-11-17 09:10
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