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【文摘发布】[J Med Virol]几丁质微粒对H5N1禽流感的
来源：J Med Virol. 2007 Apr 24;79:811-819
作者：Ichinohe T, Nagata N, Strong P, et al.
摘要：Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor-alpha. However, the mechanism of interferon-independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non-treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26-fold) after intranasal treatment with chitin microparticles. In addition, the level of IL-6 and interferon-gamma-inducible protein-10 (IP-10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper-induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 题目：Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus
题目：几丁质微粒对H5N1禽流感的预防效果
来源：J Med Virol. 2007 Apr 24;79:811-819
来源：医学病毒杂志.2007 Apr 24;79:811-819
作者：Ichinohe T, Nagata N, Strong P, et al.
Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic.
高致病性禽流感病毒（H5N1）是一种严重危害人类健康的新型治病源，并与新型流感的暴发流行有关。
This virus is resistant to the antiviral effects of interferons and tumor necrosis factor-alpha. However, the mechanism of interferon-independent protective innate immunity is not well understood.
此病毒对干扰素和肿瘤坏死因子alpha耐药。然而，不依赖干扰素的保护性天然免疫机制还并不清楚。
The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice.
研究人员应用几丁质微粒作为一种天然粘膜免疫的刺激因子，在小鼠体内研究了其对新近发现的H5N1禽流感病毒株的预防效果。
Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non-treated mice after a lethal influenza virus challenge.
经鼻内应用几丁质微粒，感染致命性流感病毒的治疗组小鼠的临床参数和存活率与非治疗组小鼠相比均有显著改善。
Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26-fold) after intranasal treatment with chitin microparticles.
流式细胞仪结果显示，经鼻内应用几丁质微粒后，表达肿瘤坏死因子（与凋亡诱导配体有关，TRAIL）及迁移至颈淋巴结的自然杀伤细胞数明显增多（26倍）。
In addition, the level of IL-6 and interferon-gamma-inducible protein-10 (IP-10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles.
另外，感染H5N1流感病毒的鼻粘膜应用几丁质微粒后，白介素6及干扰素gamma诱导蛋白10（IP-10）水平均有所降低。
These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper-induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus.
这说明鼻内预防性地给入几丁质微粒，可以促进自然杀伤细胞在局部聚集，并抑制细胞因子的高诱导状态，最终产生天然免疫反应防止H5N1的致病性。
编译后：约400字
高致病性禽流感病毒（H5N1）是一种严重危害人类健康的新型治病源，并与新型流感的暴发流行有关。此病毒对干扰素和肿瘤坏死因子alpha耐药。然而，不依赖干扰素的保护性天然免疫机制还并不清楚。研究人员应用几丁质微粒作为一种天然粘膜免疫的刺激因子，在小鼠体内研究了其对新近发现的H5N1禽流感病毒株的预防效果。经鼻内应用几丁质微粒，感染致命性流感病毒的治疗组小鼠的临床参数和存活率与非治疗组小鼠相比均有显著改善。流式细胞仪结果显示，经鼻内应用几丁质微粒后，表达肿瘤坏死因子（与凋亡诱导配体有关，TRAIL）及迁移至颈淋巴结的自然杀伤细胞数明显增多（26倍）。另外，感染H5N1流感病毒的鼻粘膜应用几丁质微粒后，白介素6及干扰素gamma诱导蛋白10（IP-10）水平均有所降低。这说明鼻内预防性地给入几丁质微粒，可以促进自然杀伤细胞在局部聚集，并抑制细胞因子的高诱导状态，最终产生天然免疫反应防止H5N1的致病性。
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作者:admin@医学,生命科学 2010-10-18 05:11
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