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【medical-news】颈动脉超声增加运动负荷试验的检
10 May 2007
MedWire News: Carotid ultrasound is a useful adjunct to exercise stress testing (EST) for detecting significant coronary artery disease (CAD), a study in symptomatic individuals has found.
Carotid intima-media thickness (CIMT), determined by ultrasound, is an established tool for screening asymptomatic patients for cardiovascular disease risk but its role in symptomatic individuals is unclear.
In the present study, Manpreet Kanwar and co-workers from Wayne State University School of Medicine in Detroit, Michigan, hypothesized that measuring CIMT could improve the ability of EST to identify symptomatic patients with ≥50% coronary diameter stenosis.
They enrolled 50 individuals with angina but no known CAD. Their pretest probability of CAD was calculated on the basis of age, gender, and nature of symptoms before undergoing diagnostic coronary angiography, carotid ultrasound, and exercise or pharmacologic stress testing.
Writing in the American Journal of Cardiology, Kanwar et al reveal that patients with a CIMT above the 75th percentile were significantly more likely to have CAD ≥50% than those with lower CIMT values (74% vs 44%, p=0.047).
Similarly, the presence of carotid plaque was associated with an increased likelihood of significant coronary stenosis (96% vs 59%, p=0.003).
Of note, carotid plaque was useful in defining risk in patients with a negative or equivocal result from stress testing. Of 38 such patients, significant CAD was detected in 46% of patients with carotid plaque versus none of those without such plaque (p=0.007).
The value of carotid ultrasound was confirmed in multivariate analysis; independent predictors of CAD ≥50% were the pretest probability of CAD, presence of carotid plaque, moderately/severely abnormal stress testing result, and hypertension.
“Carotid ultrasound appears to offer incremental value to EST in predicting presence or absence of ≥50% coronary diameter stenosis in symptomatic patients with equivocal/negative EST result,” Kanwar and co-authors conclude.
“Whether there might be a role for carotid ultrasound as an adjunctive test in all patients referred for EST deserves further study.”
Am J Cardiol 2007; 99: 1196-1200
http://www.incirculation.net/NewsItem/Carotid-ultrasound-offers-incremental-value-to-EST.aspx 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Carotid ultrasound offers incremental value to EST
颈动脉超声增加运动负荷试验的检测价值
10 May 2007
MedWire News: Carotid ultrasound is a useful adjunct to exercise stress testing (EST) for detecting significant coronary artery disease (CAD), a study in symptomatic individuals has found.
MedWire新闻：个体症状研究表明：在诊断显著的冠状动脉疾病(CAD)中，颈动脉超声是运动负荷试验(EST)有效的补充。
Carotid intima-media thickness (CIMT), determined by ultrasound, is an established tool for screening asymptomatic patients for cardiovascular disease risk but its role in symptomatic individuals is unclear.
超声测量出颈动脉内膜中层的厚度，是已建立的筛选非症状性心血管疾病风险病人的工具，但是，这个测量在有症状的个体中所扮演的角色还不清楚。
In the present study, Manpreet Kanwar and co-workers from Wayne State University School of Medicine in Detroit, Michigan, hypothesized that measuring CIMT could improve the ability of EST to identify symptomatic patients with ≥50% coronary diameter stenosis.
在最近的研究中，来自密西根州底特律市Wayne州大学医学院的 Manpreet Kanwar和他的同事假设超声测量颈动脉内膜中层厚度改良运动负荷试验在鉴定≥50%冠脉直径狭窄的有症状病人的能力。
They enrolled 50 individuals with angina but no known CAD. Their pretest probability of CAD was calculated on the basis of age, gender, and nature of symptoms before undergoing diagnostic coronary angiography, carotid ultrasound, and exercise or pharmacologic stress testing.
他们研究了50名有心绞痛但是未确定是否有冠状动脉疾病的病人。
通过病人年龄基础，性别，在经历诊断性冠状动脉造影术，颈动脉超声和运动或药物负荷试验之前的自然症状来计算他们患冠状动脉疾病的可能性
Writing in the American Journal of Cardiology, Kanwar et al reveal that patients with a CIMT above the 75th percentile were significantly more likely to have CAD ≥50% than those with lower CIMT values (74% vs 44%, p=0.047).
他们的文章发表在美国心脏病杂志上，Kanwar等人揭示了：颈动脉内膜中层的厚度在75%以上的病人和低颈动脉内膜中层厚度的病人比起来，患≥50%冠状动脉疾病的可能性显著增加(74%对44%, p=0.047)。
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作者:admin@医学,生命科学 2010-10-05 05:11
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