主页 > 医学文档 >
【文摘发布】用乙状结肠镜和大便隐血试验筛查
Authors：Segnan N, Senore C, Andreoni B, Azzoni A, Bisanti L, Cardelli A, Castiglione G, Crosta C, Ederle A, Fantin A, Ferrari A, Fracchia M, Ferrero F, Gasperoni S, Recchia S, Risio M, Rubeca T, Saracco G, Zappa M; SCORE3 Working Group-Italy.
CPO Piemonte, Torino, Italy. nereo.segnan@cpo.it
Resource：Gastroenterology. 2007 Jun;132(7):2304-12. Epub 2007 Mar 21.
BACKGROUND & AIMS: We conducted a study to estimate population coverage and detection rate (DR) achievable through different strategies of colorectal cancer (CRC) screening. METHODS: A population-based multicenter randomized trial comparing 3 strategies was used: (1) biennial immunologic fecal occult blood test (FIT), (2) "once only" sigmoidoscopy (FS), and (3) "once only" colonoscopy (TC). A random sample of men and women, aged 55 to 64 years, was drawn from general practitioners' (GP) rosters. Eligible subjects, randomized within GP, were mailed a personal invitation. Nonresponders in groups 2 and 3 were invited again at 12 and 24 months. Screenees with "high-risk" distal polyps (villous component >20%, high-grade dysplasia, CRC, size >or=10 mm, >2 adenomas) at FS, or with positive FIT, were referred for TC. RESULTS: The attendance rate was 32.3% (1965/6075) for FIT, 32.3% (1944/6018) for FS, 26.5% (1597/6021) for TC. FIT detected 2 patients with CRC (0.1%) and 21 with an advanced adenoma (1.1%). The corresponding figures were as follows: 12 (0.6%) and 86 (4.5%) patients, respectively, for FS; 13 (0.8%) and 100 (6.3%) patients, respectively, for TC. To detect 1 advanced neoplasm, it would be necessary to invite 264 people with FIT, 60 with FS, 53 with TC. FS would have detected 27.3% of the proximal advanced neoplasms detected at TC. Assuming the same participation rate at TC as at FS, 48 TCs would be necessary to detect 1 additional advanced neoplasm missed by FS. CONCLUSIONS: When participants are offered 1 screening test, participation is lower in a TC than in an FS program. However, DR of advanced neoplasia is higher with TC.
PMID: 17570205 [PubMed - in process] 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title：Comparing attendance and detection rate of colonoscopy with sigmoidoscopy and FIT for colorectal cancer screening.
用乙状结肠镜和大便隐血试验筛查结肠癌的效果比较
作者：略
Resource：Gastroenterology. 2007 Jun;132(7):2304-12. Epub 2007 Mar 21.
来源：胃肠病学 2007，132(7):2304-2312
BACKGROUND & AIMS: We conducted a study to estimate population coverage and detection rate (DR) achievable through different strategies of colorectal cancer (CRC) screening.
背景和目标：我们进行了一项研究来评估通过不同的结肠癌的筛选策略可获得的人口的覆盖度和检出率。
METHODS: A population-based multicenter randomized trial comparing 3 strategies was used: (1) biennial immunologic fecal occult blood test (FIT), (2) "once only" sigmoidoscopy (FS), and (3) "once only" colonoscopy (TC). A random sample of men and women, aged 55 to 64 years, was drawn from general practitioners' (GP) rosters.
方法：一项以人群为基础的多中心、随机试验 比较了使用的3种策略：(1) 每两年的免疫学的大便潜血试验；(2)仅仅一次的乙状结肠镜检查；(3)仅仅一次的结肠镜检查。从普通执业医师（全科医师）的花名册上挑选的，年龄在55到64岁之间的男性和女性，进行随机抽样调查。
Eligible subjects, randomized within GP, were mailed a personal invitation. Nonresponders in groups 2 and 3 were invited again at 12 and 24 months.
合格的受试者，普通执业医师（全科医师）随机化设计，通过个人邮件邀请。组2和组3中无应答者在12个月和24个月时候被重新邀请。
Screenees with "high-risk" distal polyps (villous component >20%, high-grade dysplasia, CRC, size >or=10 mm, >2 adenomas) at FS, or with positive FIT, were referred for TC.
筛选用：a.乙状结肠镜检中“高危”的远端息肉（绒毛状成分>20%，高分级的发育异常，结肠直肠癌，其大小大于或者等于10mm，超过2个腺瘤）；b. 大便潜血试验阳性，均作为结肠镜检查的参考。
RESULTS: The attendance rate was 32.3% (1965/6075) for FIT, 32.3% (1944/6018) for FS, 26.5% (1597/6021) for TC. FIT detected 2 patients with CRC (0.1%) and 21 with an advanced adenoma (1.1%). The corresponding figures were as follows: 12 (0.6%) and 86 (4.5%) patients, respectively, for FS; 13 (0.8%) and 100 (6.3%) patients, respectively, for TC.
结果：大便潜血试验的响应率是32.3％(1965/6075)，乙状结肠镜检响应率32.3% (1944/6018)，结肠镜检响应率26.5% (1597/6021)。大便潜血试验发现2例(0.1%)结肠癌患者和21例(1.1%)晚期腺瘤。接下来相应的数字分别为：乙状结肠镜检例发现12 (0.6%)例结肠癌患者和 86 (4.5%)晚期腺瘤；结肠镜检发现13例(0.8%)结肠癌患者和100 例(6.3%)晚期腺瘤。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-04-01 05:11
医学,生命科学网