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【medical-news】利尿剂不能预防先兆子痫
NEW YORK (Reuters Health) Feb 05 - Diuretics do not appear to prevent preeclampsia, contrary to the findings of an earlier nonsystematic review of randomized trials of diuretics in pregnancy, according to a report in the January 24th Cochrane Database of Systematic Research.
Dr. David Churchill from New Cross Hospital, West Midlands, UK and colleagues reviewed randomized controlled trials to ascertain whether the use of diuretics in pregnancy prevents the onset of preeclampsia.
There was no clear evidence of any difference in the rates of preeclampsia between women treated with diuretics and other women, the authors report, though there was a trend toward a reduction in preeclampsia among women receiving diuretics.
Diuretics also had no clear effect on the risk of caesarean section, perinatal death, or premature birth or gestation at delivery, the results indicate.
Women treated with diuretics were nearly 9 times as likely to have adverse drug events and nearly 6 times as likely to experience nausea and vomiting severe enough to stop treatment, the researchers note.
There were no significant differences in the diuretic and placebo groups in hypertension, severe preeclampsia, use of antihypertensive drugs, postmaturity, or low Apgar scores, the report indicates.
"There is insufficient evidence to draw reliable conclusions about the effects of diuretics for prevention of preeclampsia," the investigators write. "In addition, the incidence of side effects, particularly vomiting, was higher in the group receiving the diuretics."
"Therefore," the authors conclude, "at present, diuretics should not be recommended for this purpose in clinical practice."
The "first-line approach to reduce the risk of pre-eclampsia is low-dose aspirin," Dr. Churchill told Reuters Health. "While the evidence that diuretics prevent pre-eclampsia is lacking, they do not appear to cause any significant harm in terms of perinatal mortality."
Cochrane Database of Systematic Reviews 2007.
http://www.medscape.com/viewarticle/551726 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Diuretics Do Not Prevent Preeclampsia
利尿剂不能预防先兆子痫
NEW YORK (Reuters Health) Feb 05 - Diuretics do not appear to prevent preeclampsia, contrary to the findings of an earlier nonsystematic review of randomized trials of diuretics in pregnancy, according to a report in the January 24th Cochrane Database of Systematic Research.
纽约路透社（健康新闻）2月5日电 据1月24日发布的Cochrane荟萃分析研究报道，利尿剂不能预防先兆子痫，这与之前对利尿剂在孕妇中应用的随机临床试验的非系统评价结果正好相反。
Dr. David Churchill from New Cross Hospital, West Midlands, UK and colleagues reviewed randomized controlled trials to ascertain whether the use of diuretics in pregnancy prevents the onset of preeclampsia.
来自英国中西部地区New Cross医院的的David Churchill博士及其同事回顾了随机临床试验来探索利尿剂的使用是否能预防先兆子痫的发生。
There was no clear evidence of any difference in the rates of preeclampsia between women treated with diuretics and other women, the authors report, though there was a trend toward a reduction in preeclampsia among women receiving diuretics.
据作者报道，虽然没有明确的证据说明利尿剂的使用与否对先兆子痫的发生率有显著影响，但有认为利尿剂能降低先兆子痫发生率的倾向。
Diuretics also had no clear effect on the risk of caesarean section, perinatal death, or premature birth or gestation at delivery, the results indicate.
结果还显示，利尿剂对剖宫产术、围产期死亡或早产的风险没有明确的效果。
Women treated with diuretics were nearly 9 times as likely to have adverse drug events and nearly 6 times as likely to experience nausea and vomiting severe enough to stop treatment, the researchers note.
研究人员称，使用利尿剂的孕妇药物不良反应的发生率是安慰剂组的9倍，发生严重的恶心、呕吐被迫停药的为安慰剂组的6倍。
There were no significant differences in the diuretic and placebo groups in hypertension, severe preeclampsia, use of antihypertensive drugs, postmaturity, or low Apgar scores, the report indicates.
研究报告称，高血压、严重的先兆子痫、抗高血压药的使用、过期产、低Apgar评分在利尿剂组和安慰剂组间无显著差异。
"There is insufficient evidence to draw reliable conclusions about the effects of diuretics for prevention of preeclampsia," the investigators write. "In addition, the incidence of side effects, particularly vomiting, was higher in the group receiving the diuretics."
“目前没有可靠的证据证实利尿剂能预防先兆子痫，”研究者写到，“此外，不良反应的发生率，尤其是呕吐在利尿剂组发生率增高。”
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作者:admin@医学,生命科学 2011-02-18 12:58
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