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【文摘发布】屏气就能调节基因
氧是非常重要的，低氧参与生理和病理生理过程，为应付低氧条件，细胞和器官进化出适应和生存的能力，细胞通过控制基因的转录和转录后调节发生反应，其中有的基因发生上调，有的下调。其中最著名的转录因子是 HIF。最近接连发现一些其他的 转录因子也参与低氧反应。因此，低氧基因表达的调控是多种转录因子协调发挥作用。这些过程有小分子RNA和染色体水平上的贡献。
Rocha S.
College of Life Sciences, Division of Gene Regulation and Expression MSI/WTB/JBC Complex, Dow Street, University of Dundee, Dundee, DD1 5EH, UK.
Oxygen is both an environmental and developmental signal that governs important cellular pathways. Therefore, hypoxia (or low oxygen tensions) is part of both physiological and pathological processes. To deal with hypoxic conditions, cells and organisms have evolved exquisite mechanisms for adaptation and survival. The cellular responses are reliant on controlled transcriptional and post-transcriptional events, where certain genes are positively regulated and others either remain inactive or are actively repressed. It has been known for some time that, during hypoxia, transcription is mainly regulated by the hypoxia inducible factor (HIF). However, recently it has been demonstrated that additional transcription factors are also activated and that non-HIF-dependent processes are involved in the hypoxic stress response. Therefore, gene expression following hypoxia is the result of combined effects on transcription, translation and adjustment mechanisms such as the induction of microRNAs and changes in chromatin. 神奇！！！ [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-02-18 05:12
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