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【medical-news】新发现：2型糖尿病基因
Sun Mar 30, 2008 6:16pm EDT
研究者发现额外6个糖尿病基因：研究
By Michael Kahn
LONDON (Reuters) - U.S. and European scientists have found six more genes that make people more susceptible to developing type 2 diabetes, in a study they say may help prevent and treat the chronic condition.
伦敦（路透通讯社）－美国和欧洲科学家已经发现额外6个使人们更易于发展成2型糖尿病的基因，在一个研究中他们说可能帮助预防和治疗这种慢性疾病。
The finding extends the total number of genes linked to the disease to 16 and provides clues to how the biological mechanisms that control blood sugar levels go awry when people get type 2 diabetes, the researchers said.
研究者说，这个发现使疾病相关的基因总数扩展到16个，并为人们患2型糖尿病时控制血糖水平偏斜的生物学机制提供了线索。
"None of the genes we have found was previously on the radar screen of diabetes researchers," said Mark McCarthy, a diabetes researcher at the University of Oxford, who co-led the study.
牛津大学糖尿病研究员，辅助带领研究的Mark McCarthy说，“我们发现的基因没有一个先前存在糖尿病研究者的雷达网中”
"Each of these genes therefore provides new clues to the processes that go wrong when diabetes develops, and each provides an opportunity for the generation of new approaches for treating or preventing this condition."
“因此，这些基因中的每一个都为糖尿病发展中的错误进程提供新的线索，并且，每一个都为新的治疗或者预防这种疾病的方法的产生提供了机会”
A diabetic's blood glucose levels tend to rise too high. Too much glucose in the blood can damage the eyes, kidneys and nerves, and lead to heart disease, stroke and limb amputations.
一个糖尿病患者的血糖水平倾向于升的很高。血液中过多的葡萄糖能损伤眼睛、肾脏和神经，并导致心脏疾病、中风和截肢。
Type 2 diabetes accounts for about 90 percent of all diabetes cases and is closely linked to obesity and physical inactivity. The World Health Organisation estimates that more than 180 million people worldwide have diabetes -- a number likely to more than double by 2030.
2型糖尿病占所有糖尿病患者的数量的大约90％，并且与肥胖和身体活动减少有关。世界卫生组织估计世界范围内有超过1.8亿的人患有糖尿病－这个数据很可能到2030年翻一番。
In the study published in Nature Genetics, researchers from over 40 centers analyzed the genetic data of more than 70,000 people. The team turned up six genetic differences that each individually slightly raise a person's risk of diabetes.
在自然遗传学发表的研究中，来自40多个中心的研究者分析了超过7万患者的遗传数据。研究组出现了6个遗传学差异，每个能单独地轻度增加人的患糖尿病的危险。
But the risk for the few people unlucky enough to inherit all six variations is two to three times higher than the average risk, McCarthy said in a telephone interview.
McCarthy在一个电话采访中说，但是对于足够不幸的遗传有所有6个变异的人，患病危险是平均的2－3倍。
"By getting a handle on the mechanisms involved in disease we can start to tackle them in a more systemic and scientific way," he said.
他说，通过疾病相关机制的控制，我们能开始以一个更系统和科学的方式处理他们。
One of the surprising finds was the link between type 2 diabetes and a gene called JAZF1, which researchers recently showed plays a role in prostate cancer, the researcher added.
研究者又说，其中一个令人惊讶的发现，是2型糖尿病和一个叫做JAZF1的基因之间的联系，研究者们最近发现JAZF1在前列腺癌中起作用。
The researchers believe the genes -- which also include the CDC123-CAMK1D, TSPAN8-LGR5, THADA, ADAMTS9 and NOTCH2 genes -- are involved in regulating the number of insulin-producing cells in the pancreas, McCarthy said.
McCarthy说，研究者们相信，也包括CDC123-CAMK1D, TSPAN8-LGR5, THADA, ADAMTS9 和 NOTCH2的基因们，在胰腺中与产胰岛素细胞数量的调节有关。 编译：
研究者发现额外6个糖尿病基因：研究
By Michael Kahn
伦敦（路透通讯社）－美国和欧洲科学家已经发现额外6个使人们更易于发展成2型糖尿病的基因，在一个研究中他们说可能帮助预防和治疗这种慢性疾病。
研究者说，这个发现使疾病相关的基因总数扩展到16个，并为人们患2型糖尿病时控制血糖水平偏斜的生物学机制提供了线索。牛津大学糖尿病研究员，辅助带领研究的Mark McCarthy说，“我们发现的基因没有一个先前存在糖尿病研究者的雷达网中”“因此，这些基因中的每一个都为糖尿病发展中的错误进程提供新的线索，并且，每一个都为新的治疗或者预防这种疾病的方法的产生提供了机会”
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作者:admin@医学,生命科学 2011-02-15 05:14
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