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【medical-news】NEJM：抑制HSV-2不能阻止HIV感染
ABSTRACT
Background
Infection with herpes simplex virus type 2 (HSV-2) is associated with an increased risk of acquiring infection with the human immunodeficiency virus (HIV). This study tested the hypothesis that HSV-2 suppressive therapy reduces the risk of HIV acquisition.
Methods
Female workers at recreational facilities in northwestern Tanzania who were 16 to 35 years of age were interviewed and underwent serologic testing for HIV and HSV-2. We enrolled female workers who were HIV-seronegative and HSV-2–seropositive in a randomized, double-blind, placebo-controlled trial of suppressive treatment with acyclovir (400 mg twice daily).
Participants attended mobile clinics every 3 months for a follow-up period of 12 to 30 months, depending on enrollment date. The primary outcome was the incidence of infection with HIV. We used a modified intention-to-treat analysis; data for participants who became pregnant were censored. Adherence to treatment was estimated by a tablet count at each visit.
Results
A total of 821 participants were randomly assigned to receive acyclovir (400 participants) or placebo (421 participants); 659 (80%) completed follow-up. Mean follow-up for the acyclovir and placebo groups was 1.52 and 1.62 years, respectively. The incidence of HIV infection was 4.27 per 100 person-years (27 participants in the acyclovir group and 28 in the placebo group), and there was no overall effect of acyclovir on the incidence of HIV (rate ratio for the acyclovir group, 1.08; 95% confidence interval, 0.64 to 1.83). The estimated median adherence was 90%. Genital HSV was detected in a similar proportion of participants in the two study groups at 6, 12, and 24 months. No serious adverse events were attributable to treatment with acyclovir.
Conclusions
These data show no evidence that acyclovir (400 mg twice daily) as HSV suppressive therapy decreases the incidence of infection with HIV.
http://content.nejm.org/cgi/content/full/NEJMoa0800260 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Effect of Herpes Simplex Suppression on Incidence of HIV among Women in Tanzania
坦桑尼亚女性群体中HSV对HIV发病率的影响
ABSTRACT摘要
Background背景
Infection with herpes simplex virus type 2 (HSV-2) is associated with an increased risk of acquiring infection with the human immunodeficiency virus (HIV). This study tested the hypothesis that HSV-2 suppressive therapy reduces the risk of HIV acquisition.
HSV-2感染与获得性HIV感染的相关性风险增高。这项研究用来检验这个假说：抗HSV-2治疗减少感染HIV的风险。
Methods 方法
Female workers at recreational facilities in northwestern Tanzania who were 16 to 35 years of age were interviewed and underwent serologic testing for HIV and HSV-2. We enrolled female workers who were HIV-seronegative and HSV-2–seropositive in a randomized, double-blind, placebo-controlled trial of suppressive treatment with acyclovir (400 mg twice daily).
随访坦桑尼亚西北部地区年龄介于16-35岁的娱乐场所女性工作者，并接受HIV和HSV-2血清学检测。我们登记HIV血清阴性、HSV-2血清学检测阳性的个体入组，随机双盲，安慰剂－受控治疗，抗病毒使用阿昔洛维（400mg 2/日）。
Participants attended mobile clinics every 3 months for a follow-up period of 12 to 30 months, depending on enrollment date. The primary outcome was the incidence of infection with HIV. We used a modified intention-to-treat analysis; data for participants who became pregnant were censored. Adherence to treatment was estimated by a tablet count at each visit. We used a modified intention-to-treat analysis; data for participants who became pregnant were censored. Adherence to treatment was estimated by a tablet count at each visit.
我们采用了修正的ITT分析，怀孕的受试者的数据被排除。每次检查时，治疗的依存性通过数片法进行估计。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-01-28 17:14
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