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【Science】推介论文：生物钟神话
Our circadian rhythms keep us in tune with the day. Some of the molecular signals that implement and regulate the circadian rhythm have been identified, but the complexity of the various systems affected by circadian rhythms is not well understood. Many people work against their circadian clock, whether it be a scientist who hops seven time zones eastward and still hopes to be awake at a conference session with the lights dimmed, or someone who works the night shift and needs cognitive acuity and physical dexterity during the hours when most of us are asleep. To further understand how disruption of the circadian rhythm affects us, Karatsoreos et al. studied mice kept in an unnaturally short day/night cycle. With a cycle of 20 rather than 24 hours, the mice showed a variety of disrupted responses. They gained weight, had elevated insulin levels, and demonstrated reduced cognitive flexibility. Neurons in the brain's cortex showed reduced complexity. Study of these mice may help us understand, for example, the unexpected incidence of obesity among shift workers.
原文
Karatsoreos IN, Bhagat S, Bloss EB, Morrison JH, McEwen BS. 2011. Disruption of circadian clocks has ramifications for metabolism, brain, and behavior. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1657-1662. Epub 2011 Jan 10.http://www.ncbi.nlm.nih.gov/pubmed/21220317 （见附件）
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作者:admin@医学,生命科学 2011-01-28 08:48
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