Inflammatory Bowel Disorders (IBD), includes Crohn's disease and ulcerative colitis. Chron's disease is a chronic inflammatory disease of the intestines. It primarily causes ulcerations (breaks in the lining) of the small and large intestines, but can affect the digestive system anywhere from the mouth to the anus. It is named after the physician who first described the disease in 1932. Chron's disease is sometimes also known as granulomatous enteritis or colitis, regional enteritis, ileitis, or terminal ileitis. Ulcerative colitis is another chronic inflammatory condition, involving only the colon. IBD affects approximately 500,000 to 2 million people in the United States.
The exact cause of IBD is unknown. Some scientists suspect it may be triggered by infections from certain bacteria, but definitive evidence to support this is lacking. IBD may also be caused by autoimmune reactions. The immune system normally defends the body against harmful bacteria, viruses, fungi, and other foreign invaders. However, if the body's own tissues are mistakenly recognized as "foreign," an autoimmune disease can result. In the case of IBD, the immune system attacks the cells lining the digestive tract. Recent research suggests inflammatory bowel disorders may also involve genetic predisposing factors.
Currently there is no medical cure for IBD, and current treatments are not very effective. Once the diseases begin, they tend to fluctuate between periods of inactivity (remission) and activity (relapse); the treatment goal is to promote longer periods of remission and reduce the frequency and duration of relapses. Current approaches include treatment, as necessary, with anti-inflammatory medications, immune suppressing agents, anti-diarrheal medications and/or other drugs. Dietary modifications, such as reducing fiber intake and consuming a liquid diet, can be helpful. If portions of the intestine become severely diseased, surgery may be required.
Because IBD involves immune system destruction of cells in the intestine, stem cell therapy has the potential to help treat the disease by regenerating some of the destroyed tissue and/or favorably modulating the immune system so it is less prone to attacking the intestinal cells. Clinical experience to date suggests stem cell therapy for inflammatory bowel disorders can promote longer periods of remission and reduce the frequency and duration of relapses.
A recent study at Northwestern University showed strong efficacy for the treatment of Chron's disease using stem cell transplantation. In this study, eleven of 12 patients entered a sustained remission. At a median follow-up of 18.5 months, only one patient had developed a recurrence of active Crohn's. This led researchers to conclude that stem cell therapy may be used as a safe and effective treatment for this condition.
最近有西北大学的一项研究表明： 通过干细胞移植能有效地对克隆病进行治疗，在这项研究中，12例实验病例中11例进入持续的缓解期，中位缓解期高达18.5个月，只有一例病人发展为克隆病反复复发期，该结果使研究人员相信干细胞治疗将是一种安全有效的治疗炎性肠病的方法。 [标签:content1][标签:content2]
作者:admin@医学,生命科学 2011-08-22 06:39