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【Cancer research】手术中,癌症细胞脱落可导致继发
Sometimes during surgery to remove a tumor, cells become detached from the bulk of the tumor. In a small number of cases, these tumor cells stick to cells at the site of the surgical wound and go on to form a secondary tumor, having an enormous negative impact on the survival and quality of life of the patient.
New data, generated by Marc Basson and colleagues, at the John D. Dingell VA Medical Center and Wayne State University, Detroit, using a mouse model of surgery to remove a colon cancer tumor, suggest that perioperative treatment with a drug known as colchicine might decrease the incidence of tumor formation at the site of the surgical wound.
When colon cancer tumor cells are exposed to high pressure they exhibit an increased ability to stick to other cells. In the study, to mimic the conditions of surgery, the authors removed colon cancer cells from one mouse, exposed them to high pressure in vitro, and then transplanted them into a second mouse that they monitored for the development of tumors at the site of the surgical wound.
The most important observation made was that if the mice from which the colon cancer cells came from were treated perioperatively with colchicine there was a dramatic decrease in the number of tumors that formed at the site of the surgical wound in the second mouse.
As in vitro exposure of tumor cells from breast and head and neck cancers to high pressure also increases their ability to stick to other cells it is possible that these data might have implications in several clinical settings. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Helping Tumor Cells Not To Stick To The Wound During Surgical Removal
手术中,癌症细胞脱落可导致继发性肿瘤的形成
Sometimes during surgery to remove a tumor, cells become detached from the bulk of the tumor. In a small number of cases, these tumor cells stick to cells at the site of the surgical wound and go on to form a secondary tumor, having an enormous negative impact on the survival and quality of life of the patient.
有时，在手术切除肿瘤过程中肿瘤细胞可以从肿瘤肿块中脱落。在小部分病例中，这些肿瘤细胞黏附在切口部位的细胞上，接着形成继发性肿瘤，对患者的生存率和生活治疗都有非常大的负面影响。
New data, generated by Marc Basson and colleagues, at the John D. Dingell VA Medical Center and Wayne State University, Detroit, using a mouse model of surgery to remove a colon cancer tumor, suggest that perioperative treatment with a drug known as colchicine might decrease the incidence of tumor formation at the site of the surgical wound.
John D. Dingell VA 医疗中心和位于底特律的韦恩州立大学（Wayne State University, Detroit）的Marc Basson和同事们使用了手术切除结肠癌的小鼠模型得出新的数据，结果表明：手术中应用秋水仙碱可能减少手术切口部位肿瘤继发的形成。
When colon cancer tumor cells are exposed to high pressure they exhibit an increased ability to stick to other cells. In the study, to mimic the conditions of surgery, the authors removed colon cancer cells from one mouse, exposed them to high pressure in vitro, and then transplanted them into a second mouse that they monitored for the development of tumors at the site of the surgical wound.
当结肠癌细胞增殖达到较高的压力时就会增加侵袭其它细胞的能力。在这项研究中，为了模拟手术的状态，作者切除一只小鼠的肿瘤组织，在体外促使肿瘤细胞增殖并达到较高的压力，然后移植给另一只小鼠，并检测手术切口部位肿瘤的发展情况。
The most important observation made was that if the mice from which the colon cancer cells came from were treated perioperatively with colchicine there was a dramatic decrease in the number of tumors that formed at the site of the surgical wound in the second mouse.
最重要的发现就是接受过结肠癌细胞与移植的小鼠如果术前经过秋水仙碱治疗，那么这样的小鼠手术切口的肿瘤继发的机率就会显著减少。
As in vitro exposure of tumor cells from breast and head and neck cancers to high pressure also increases their ability to stick to other cells it is possible that these data might have implications in several clinical settings.
因为在体外实验中，乳腺癌、头颈部癌细胞增殖达到较高压力后同样也会增加侵袭其他细胞的能力，所以这些研究数据有可能会对一些临床治疗提供参考。
编译：
手术中,癌症细胞脱落可导致继发性肿瘤的形成
有时，在手术切除肿瘤过程中肿瘤细胞可以从肿瘤肿块中脱落。在小部分病例中，这些肿瘤细胞黏附在切口部位的细胞上，接着形成继发性肿瘤，对患者的生存率和生活治疗都有非常大的负面影响。
John D. Dingell VA 医疗中心和位于底特律的韦恩州立大学（Wayne State University, Detroit）的Marc Basson和同事们使用了手术切除结肠癌的小鼠模型得出新的数据，结果表明：手术中应用秋水仙碱可能减少手术切口部位肿瘤继发的形成。
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作者:admin@医学,生命科学 2011-02-27 05:14
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