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【文摘发布】小儿腐蚀性食管炎维持治疗的第一
Authors: Orenstein SR.
Resource: Am J Gastroenterol. 2007 Jun;102:1298-300
Abstract:
In children, as in adults, gastroesophageal reflux disease (GERD), particularly erosive esophagitis, is now believed to be a chronic disease, probably requiring lifelong maintenance therapy. However, this assumption has not received adequate clinical testing, and the provocative article by Boccia et al. in this issue of the Journal challenges it. The strengths of this exceptional pediatric study lie in its prospective, controlled, randomized character, and in its relatively long duration of prospective follow-up. Weaknesses of the study include its limited power and lack of prior validation of outcome measures. The conclusions of the study are applicable only to children without chronic neurologic, respiratory, or congenital esophageal abnormalities, the children for whom chronic proton pump inhibitors (PPIs) are most often required. The study's provocative results might be explained by the fundamental lack of GERD chronicity in otherwise healthy children, combined with absence of the PPI dependence that can be produced when PPIs are used chronically for chronic disease.
PMID: 17531014 [PubMed - in process] 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title: Pediatric erosive esophagitis maintenance: finally, some level 1 evidence
题目：小儿腐蚀性食管炎维持治疗的第一手资料
Authors: Orenstein SR
作者：Orenstein SR
Resource: Am J Gastroenterol. 2007 Jun;102:1298-300
来源：美国胃肠病杂志.2007 Jun;102:1298-300
Abstract:
In children, as in adults, gastroesophageal reflux disease (GERD), particularly erosive esophagitis, is now believed to be a chronic disease, probably requiring lifelong maintenance therapy.
摘要：
小儿胃食管反流性疾病(GERD)，特别是腐蚀性食管炎与成人一样，被认为是一种慢性疾病，可能需要终生的维持治疗。
However, this assumption has not received adequate clinical testing, and the provocative article by Boccia et al. in this issue of the Journal challenges it. The strengths of this exceptional pediatric study lie in its prospective, controlled, randomized character, and in its relatively long duration of prospective follow-up.
然而，这种说法并没有充足的临床试验证据，Boccia等人在本杂志本期发表的争议性的论文对此提出了挑战。此项优秀的儿科研究证据有力，这本研究具有前瞻性、对照和随机的特性，而且具有相对较长的前瞻性随访时间。
Weaknesses of the study include its limited power and lack of prior validation of outcome measures. The conclusions of the study are applicable only to children without chronic neurologic, respiratory, or congenital esophageal abnormalities, the children for whom chronic proton pump inhibitors (PPIs) are most often required.
此研究的缺陷包括结果检测方面不够有力及缺乏事先的证实。此研究的结论仅适用于没有慢性神经疾病、呼吸疾病或先天性食管异常的儿童，这类儿童往往需要使用慢性质子泵抑制剂(PPIs)。
The study's provocative results might be explained by the fundamental lack of GERD chronicity in otherwise healthy children, combined with absence of the PPI dependence that can be produced when PPIs are used chronically for chronic disease.
以下方面或许可解释本研究的争议性，如不同健康儿童GERD慢性化的根本缺乏，而且伴有PPI依赖性的丧失，后者可发生于PPIs在慢性疾病中的长期使用。
编译后：共336字
Orenstein SR及其同事对小儿腐蚀性食管炎的维持治疗进行了评述，结果发表在2007.6的《美国胃肠病杂志》。小儿胃食管反流性疾病(GERD)，特别是腐蚀性食管炎与成人一样，被认为是一种慢性疾病，可能需要终生的维持治疗。然而，这种说法并没有充足的临床试验证据，Boccia等人在本杂志本期发表的争议性的论文对此提出了挑战。此项优秀的儿科研究证据有力，这本研究具有前瞻性、对照和随机的特性，而且具有相对较长的前瞻性随访时间。此研究的缺陷包括结果检测方面不够有力及缺乏事先的证实。此研究的结论仅适用于没有慢性神经疾病、呼吸疾病或先天性食管异常的儿童，这类儿童往往需要使用慢性质子泵抑制剂(PPIs)。以下方面或许可解释本研究的争议性，如不同健康儿童GERD慢性化的根本缺乏，而且伴有PPI依赖性的丧失，后者可发生于PPIs在慢性疾病中的长期使用。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-02-15 05:11
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