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【bio-news】科学家定位精神分裂症基因
Scientists locate schizophrenia gene
By Julie Steenhuysen in Chicago
March 21, 2007 09:05am
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The key to schizophrenia may be found in a gene region thought to play a role in inflammation and autoimmune disorders.
If confirmed, the finding could lead to a test and possibly new treatments for the mental disorder that affects about 1 percent of the world's population, US researchers said.
Schizophrenia, a disease marked by distorted thinking, hallucinations and reduced ability to feel normal emotions, has long been associated with heredity. But the link to inflammation might help explain why many patients with schizophrenia have autoimmune diseases.
In a study published in the journal Molecular Psychiatry scientists used a research technique called whole genome association to search the entire human genome of 178 patients with schizophrenia and 144 healthy volunteers.
Of 500,000 genetic variants studied, researchers zeroed in on a gene near the tip of both the X and Y chromosomes, which determine gender.
"That is a region that had not been looked at in schizophrenia so much," said Todd Lencz, an investigator at the Feinstein Institute for Medical Research in Manhasset, New York, and lead author of the study.
Mr Lencz said the variant was located near genes that produce receptors for two cytokines, which are involved in the body's response to infection and may play a role in the brain's response to injury.
Receptors are molecular doorways that cytokines use to attach to cells. Cytokines are immune system signaling chemicals and their production is a first step in causing inflammation.
Mr Lencz and colleagues using gene sequencing technology on a separate group of 71 schizophrenia patients and 31 healthy volunteers.
That study turned up multiple gene abnormalities in patients with schizophrenia that were not found, or were found less often, in healthy patients.
Peter McGuffin, a professor of psychiatric genetics at Kings College London in Britain, said the study may have been too small to draw any conclusions about the genetic origins of schizophrenia.
"I'd worry that this will turn out to be a false positive," McGuffin said.
Mr Lencz said the findings need to be replicated in other studies. He said he and colleagues have obtained funding to test more patients.
The study was the result of an academic-industry collaboration involving a unit of the biotechnology company Clinical Data Inc., which is seeking a patent related to the findings. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Scientists locate schizophrenia gene
科学家定位精神分裂症基因
By Julie Steenhuysen in Chicago
March 21, 2007 09:05am
2007年3月21日,上午9:05
Article from: ReutersFont
文章来源:ReutersFont
The key to schizophrenia may be found in a gene region thought to play a role in inflammation and autoimmune disorders.
引起精神分裂症的关键基因可能存在于被人们认为在炎症和自身免疫失调症中起重要作用的基因区中.
If confirmed, the finding could lead to a test and possibly new treatments for the mental disorder that affects about 1 percent of the world's population, US researchers said.
若被证实,则此发现可能会通过试验并形成一种新的精神障碍的治疗方法,目前这种精神障碍影响着约1% 的世界人口,美国的研究人员说.
Schizophrenia, a disease marked by distorted thinking, hallucinations and reduced ability to feel normal emotions, has long been associated with heredity. But the link to inflammation might help explain why many patients with schizophrenia have autoimmune diseases.
精神分裂症主要以思维扭曲,幻觉和正常情感的感知能力降低为标志, 长期以来被认为与遗传有关. 但其基因定位与炎症基因定位的联系可能有助于解释为什么许多精神分裂症患者伴有自身免疫性疾病.
In a study published in the journal Molecular Psychiatry scientists used a research technique called whole genome association to search the entire human genome of 178 patients with schizophrenia and 144 healthy volunteers.
在一项发表在<<分子精神病学>>的研究里,科学家运用一种名为全基因组关联研究的研究技术搜索了178例精神分裂症病人和144个健康志愿者的全基因组基因.
Of 500,000 genetic variants studied, researchers zeroed in on a gene near the tip of both the X and Y chromosomes, which determine gender.
在研究的50万个遗传变异基因中,研究者对准了决定性别的X和Y染色体端部的基因.
"That is a region that had not been looked at in schizophrenia so much," said Todd Lencz, an investigator at the Feinstein Institute for Medical Research in Manhasset, New York, and lead author of the study.
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