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【文摘发布】采用流化床进行湿法制粒研究：粘
http://www.sciencedirect.com/science/journal/03785173
Title：Experimental study of wet granulation in fluidized bed: Impact of the binder properties on the granule morphology
Author：P. Rajniaka, , , C. Mancinellia, R.T. Cherna, F. Stepanekb, L. Farbera and B.T. Hilla
Resource:International Journal of Pharmaceutics，334（1-2）: 92-102
Abstract：
In this work, the effect of the physicochemical properties of aqueous hydroxypropyl-cellulose (HPC) binder solutions and different pharmaceutical excipients (mannitol and anhydrous CaHPO4) on the agglomeration kinetics and granule properties were investigated. First, a particle size distribution (PSD) analysis together with a detailed analysis of morphological properties of the excipient particles were performed. Second, the viscosity, density, surface tension and size of the spray droplets of binder solutions with different HPC concentrations were determined and wetting characteristics of the binders on the excipients were measured. Third, several fluid bed wet granulation experiments were conducted for pure excipients and their blends with binder solution of different HPC concentrations in a pilot plant Wurster granulator. The observed granule growth for different binder concentrations was a strong function of the binder concentration and the excipient solubility. For mannitol, a significant “coating” period followed by a slow granule growth was observed for the case with the diluted 5% binder. The “coating” period was significantly shorter for the 10% HPC binder and did not exist for the 15% HPC for which immediate and fast granule growth was observed. For anhydrous CaHPO4 (trademark A-TA, no growth was observed for the 10% HPC binder and a long coating period followed by fast granule growth was observed for the 15% HPC. Simple physically based criteria were also evaluated, which employ the morphological properties of excipients (size and surface roughness) together with physical properties of the used binder for prediction of the coating versus agglomeration regime at given flow conditions (collision velocity). As expected, a preferential coalescence and growth of the mannitol granules from the blend of mannitol + A-TAB was observed. Finally, the mechanical and morphological properties of the produced granules were measured and correlated to the HPC concentration of the binder used in the experiments. A clear correlation between the granule porosity (evaluated by X-ray tomography) and the binder concentration was found for the mannitol granules.
PMID:17207948 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 http://www.sciencedirect.com/science/journal/03785173
Title：Experimental study of wet granulation in fluidized bed: Impact of the binder properties on the granule morphology
标题：采用流化床进行湿法制粒研究：粘合剂性质对颗粒形态学的影响
Author：P. Rajniaka, , , C. Mancinellia, R.T. Cherna, F. Stepanekb, L. Farbera and B.T. Hilla
作者：P. Rajniaka, , , C. Mancinellia, R.T. Cherna, F. Stepanekb, L. Farbera and B.T. Hilla
Resource: International Journal of Pharmaceutics，334（1-2）: 92-102
出处：国际制药学杂志，334（1-2）：92-102.
Abstract：
摘要：
In this work, the effect of the physicochemical properties of aqueous hydroxypropyl-cellulose (HPC) binder solutions and different pharmaceutical excipients (mannitol and anhydrous CaHPO4) on the agglomeration kinetics and granule properties were investigated.
在此项试验中，对黏合剂羟丙基纤维素（HPC）水溶液及不同药用辅料（甘露醇和无水磷酸氢钙）的理化性质对附聚动力学和颗粒性质的影响进行了研究。
First, a particle size distribution (PSD) analysis together with a detailed analysis of morphological properties of the excipient particles were performed.
首先，结合辅料颗粒形态特性的细微分析，对颗粒粒径分布（PSD）进行分析。
Second, the viscosity, density, surface tension and size of the spray droplets of binder solutions with different HPC concentrations were determined and wetting characteristics of the binders on the excipients were measured.
第二，对不同浓度的HPC溶液的黏性，密度，表面张力和雾滴大小进行测定，并测量黏合剂对辅料的润湿特性。
Third, several fluid bed wet granulation experiments were conducted for pure excipients and their blends with binder solution of different HPC concentrations in a pilot plant Wurster granulator. The observed granule growth for different binder concentrations was a strong function of the binder concentration and the excipient solubility.
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作者:admin@医学,生命科学 2010-12-18 17:11
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