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【medical-news】女性绝经前切除卵巢增加帕金森病
NEW YORK (Reuters Health) Jan 23 - Women who undergo unilateral or bilateral oophorectomy prior to menopause appear to be at increased risk of parkinsonism, investigators at Mayo Clinic College of Medicine, Rochester, Minnesota, report.
Numerous animal studies have indicated estrogenic neuroprotection in the nigrostriatal pathway associated with reduced risk for Parkinson's disease, Dr. W. A. Rocca and associates note in the January 15th issue of Neurology, but evidence from clinical and epidemiologic studies has been inconclusive.
To provide more insight into these issues, they studied the effect of oophorectomy prior to menopause onset. The case-control study included premenopausal women who had undergone unilateral oophorectomy (n= 1252) or bilateral oophorectomy (n = 1075), and 2368 age-matched controls. All of the women were born before 1962, and surgery was performed between 1950 and 1987 for indications other than ovarian cancer or other estrogen-related cancer.
The risk of parkinsonism was significantly increased following oophorectomy (hazard ratio 1.68), with a trend toward increased risk with younger age at surgery.
"The findings were similar regardless of the indication for the oophorectomy, and for unilateral or bilateral oophorectomy considered separately," the investigators write.
They suggest that the premature estrogen deficiency caused by the removal of the ovaries robs neurons of the protective benefits associated with the hormone, thereby raising the risk of parkinsonism and other neurologic disorders.
"This study is one of the first to support the hypothesis of a critical age window for the protective effect of estrogen on the nigrostriatal pathway in humans," Dr. Rocca's team points out. "However, independent replication of our findings is needed before they can be considered in guiding gynecological practices."
Neurology 2008;70:200-209.
http://www.medscape.com/viewarticle/569122 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Oophorectomy Before Menopause May Raise Parkinsonism Risk
绝经前卵巢切除可能增加患帕金森综合症的风险
NEW YORK (Reuters Health) Jan 23 - Women who undergo unilateral or bilateral oophorectomy prior to menopause appear to be at increased risk of parkinsonism, investigators at Mayo Clinic College of Medicine, Rochester, Minnesota, report.
纽约（路透社健康专栏）1月23日-明尼苏达州Rochester梅奥临床医学院的研究人员报道，绝经前遭受单侧或双侧卵巢切除的妇女表现为患帕金森综合症的风险增加。
Numerous animal studies have indicated estrogenic neuroprotection in the nigrostriatal pathway associated with reduced risk for Parkinson's disease, Dr. W. A. Rocca and associates note in the January 15th issue of Neurology, but evidence from clinical and epidemiologic studies has been inconclusive.
W. A. Rocca博士和同伴在1月15日的《神经病学》杂志上写道，很多动物研究表明雌激素在黑质纹状体通路的神经保护作用与降低帕金森病的风险有关联，但是来自临床和流行病学研究的证据还没得出结论。
To provide more insight into these issues, they studied the effect of oophorectomy prior to menopause onset. The case-control study included premenopausal women who had undergone unilateral oophorectomy (n= 1252) or bilateral oophorectomy (n = 1075), and 2368 age-matched controls. All of the women were born before 1962, and surgery was performed between 1950 and 1987 for indications other than ovarian cancer or other estrogen-related cancer.
为更深入的了解这些问题，他们研究了绝经开始前卵巢切除的影响。病例对照研究包括遭受单侧卵巢（n=1252）或双侧卵巢（n=1075）切除的绝经期的妇女和2368名年龄相当的对照。所有这些妇女都是1962年以前出生的，手术时间是在1950到1987年之间，适应症除外卵巢癌或其他雌激素相关的癌症。
The risk of parkinsonism was significantly increased following oophorectomy (hazard ratio 1.68), with a trend toward increased risk with younger age at surgery.
卵巢切除后帕金森综合症的危险明显地增加（危害比1.68），伴随有一个风险随手术年龄减小而增加的趋势。
"The findings were similar regardless of the indication for the oophorectomy, and for unilateral or bilateral oophorectomy considered separately," the investigators write.
“这一发现结果是相似的，不管卵巢切除的适应症和单侧或双侧卵巢切除分开考虑，”研究者写道。
They suggest that the premature estrogen deficiency caused by the removal of the ovaries robs neurons of the protective benefits associated with the hormone, thereby raising the risk of parkinsonism and other neurologic disorders.
他们提示卵巢去除导致的过早雌激素缺乏剥夺了与激素相关神经元保护，从而增加了帕金森综合症和其他神经系统紊乱的危险。
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作者:admin@医学,生命科学 2010-11-04 17:11
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