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【Nat Rev Cancer】过继性细胞治疗：激活癌症免疫治
Adoptive cell therapy (ACT) using autologous tumour-infiltrating lymphocytes has emerged as the most effective treatment for patients with metastatic melanoma and can mediate objective cancer regression in approximately 50% of patients. The use of donor lymphocytes for ACT is an effective treatment for immunosuppressed patients who develop post-transplant lymphomas. The ability to genetically engineer human lymphocytes and use them to mediate cancer regression in patients, which has recently been demonstrated, has opened possibilities for the extension of ACT immunotherapy to patients with a wide variety of cancer types and is a promising new approach to cancer treatment.
http://www.nature.com/nrc/journal/v8/n4/abs/nrc2355.html 本人已认领该文编译，24小时后若未提交译文，请其他战友自由认领 Adoptive cell transfer: a clinical path to effective cancer immunotherapy
过继性细胞回输：激活癌症免疫治疗有效的临床途径
Adoptive cell therapy (ACT) using autologous tumour-infiltrating lymphocytes has emerged as the most effective treatment for patients with metastatic melanoma and can mediate objective cancer regression in approximately 50% of patients. The use of donor lymphocytes for ACT is an effective treatment for immunosuppressed patients who develop post-transplant lymphomas. The ability to genetically engineer human lymphocytes and use them to mediate cancer regression in patients, which has recently been demonstrated, has opened possibilities for the extension of ACT immunotherapy to patients with a wide variety of cancer types and is a promising new approach to cancer treatment.
过继性细胞治疗（ACT）利用自体肿瘤浸润的淋巴细胞。本法成为治疗转移性黑色素瘤最有效的方法，并可抑制约50%的患者复发。利用捐献者的淋巴细胞进行ACT是一种对建立移植后淋巴结的免疫抑制患者的有效治疗方法。近期证实，通过遗传工程构建人类淋巴细胞并利用这些细胞阻止患者复发是一种可行的方法。这扩大了ACT免疫疗法治疗各种肿瘤患者的可能性，并且是一种比较有前景的肿瘤治疗新方法。 在nicolelee 基础上，另一版本，参考一下
Adoptive cell therapy (ACT) using autologous tumour-infiltrating lymphocytes has emerged as the most effective treatment for patients with metastatic melanoma and can mediate objective cancer regression in approximately 50% of patients. The use of donor lymphocytes for ACT is an effective treatment for immunosuppressed patients who develop post-transplant lymphomas. The ability to genetically engineer human lymphocytes and use them to mediate cancer regression in patients, which has recently been demonstrated, has opened possibilities for the extension of ACT immunotherapy to patients with a wide variety of cancer types and is a promising new approach to cancer treatment.
利用自体肿瘤浸润的淋巴细胞过继性细胞治疗成为治疗转移性黑色素瘤最有效的方法，并可使约50%的患者目标肿瘤缩小。利用供者淋巴细胞进行ACT是一种对免疫抑制患者发生移植后淋巴瘤的有效治疗方法。近期发现，利用基因工程改造过的淋巴细胞并利用这些细胞缩小患者肿瘤，开创了用扩展的ACT免疫疗法治疗各种肿瘤患者的可能性，并且是一种很有前景的肿瘤治疗新方法。 不错呢！ [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-09-18 05:15
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