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【文摘发布】目前用于检测气道重构的技术
Author:C. Bergeron1, M. K. Tulic2 and Q. Hamid1
Abstract:
Airway remodelling refers to changes in the airway structure and includes subepithelial fibrosis, increased smooth muscle mass, submucosal gland enlargement, neovascularisation and epithelial alterations. Remodelling is observed in response to chronic injury and is seen not only in asthma but in all airway diseases.
Remodelling is associated with more severe airflow obstruction and airway hyperresponsiveness in asthma; however, the clinical significance of this is still a matter of debate. Research should be pursued to better understand the accurate implication of airway remodelling in disease and its therapeutic modulation.
To allow research in this field, accurate and standardised methods should be utilised to measure airway alterations in disease and following therapy. The standard detection of structural alterations is through direct analyses of airway tissues obtained during a post mortem, surgically or by flexible bronchoscopy. To avoid invasive techniques, other tools have been developed to indirectly measure remodelling, including induced sputum, bronchoalveolar lavage fluid, blood and urine analyses, physiological and radiological assessments, as well as in vitro techniques.
Although of great interest, the exact significance of airway remodelling measurements gained through such indirect techniques is uncertain and further research is needed. Despite their invasive nature, direct methods should be favoured to adequately measure airway remodelling in disease and its modulation by therapy.
Eur Respir J 2007; 29: 596–604
认领的站友可pm我获全文。 我认领了,谢谢!24小时候若没有翻译出请别的战友自由认领! 题目:研究中检测气道重构的技术
作者：C. Bergeron1, M. K. Tulic2 and Q. Hamid1
摘要：
气道重构指气道结构的改变，包括：上皮下纤维化，平滑肌增厚，粘膜下腺体肥大，新生血管形成和上皮的变化。（呼吸道的）慢性创伤会引起气道的重构，气道重构不仅见于哮喘患者，也见于所有呼吸道疾病患者中。
在哮喘患者中，气道重构伴随着气道阻力和气道高反应性的加重；然而，它在临床上的重要意义至今仍有争议。为了更好地了解在疾病中一旦出现气道重构会带来的后果和针对它的治疗方案，还有必要进行研究。
在这一领域进行研究，需要使用精确和标准化的检测方法用以测定在疾病中和治疗后气道的改变。对于气道结构变化的标准检测方法是对气道组织进行检测，气道组织通过患者死后获取，或是经由手术、纤支镜活检得到。为了避免上述的有创检查，目前已发展了其它的检测方法来间接的评估气道重构，包括对患者诱导痰的检测、支气管肺泡灌洗液检查，血液和尿液化验、生理学和放射学方面的检查以及一些离体的检查技术。
上述对于气道重构的间接检测技术虽然引起了研究者广泛的兴趣，但由这些技术测定出的气道重构对临床的确切意义还没有确定，这还需要进一步的研究。虽然这些是无创的检查，但是使用直接的检测技术以更充分的测定在疾病中气道重构的发生和治疗后气道重构的改善还是更受推崇的。
Eur Respir J 2007; 29: 596–604
如有不当之处，敬请指正！ Despite their invasive nature, direct methods should be favoured to adequately measure airway remodelling in disease and its modulation by therapy。
第一部分应该是 尽管它们有创的 请ilmz战友将译文按照中英文对照格式贴出。 Title:Tools used to measure airway remodelling in research
题目:研究中检测气道重构的技术
Author:C. Bergeron1, M. K. Tulic2 and Q. Hamid1
作者：C. Bergeron1, M. K. Tulic2 and Q. Hamid1
Abstract:
摘要:
Airway remodelling refers to changes in the airway structure and includes subepithelial fibrosis, increased smooth muscle mass, submucosal gland enlargement, neovascularisation and epithelial alterations. Remodelling is observed in response to chronic injury and is seen not only in asthma but in all airway diseases.
气道重构指气道结构的改变，包括：上皮下纤维化，平滑肌增厚，粘膜下腺体肥大，新生血管形成和上皮的变化。（呼吸道的）慢性创伤会引起气道的重构，气道重构不仅见于哮喘患者，也见于所有呼吸道疾病患者中。
Remodelling is associated with more severe airflow obstruction and airway hyperresponsiveness in asthma; however, the clinical significance of this is still a matter of debate. Research should be pursued to better understand the accurate implication of airway remodelling in disease and its therapeutic modulation.
在哮喘患者中，气道重构伴随着气道阻力和气道高反应性的加重；然而，它在临床上的重要意义至今仍有争议。为了更好地了解在疾病中一旦出现气道重构会带来的后果和针对它的治疗方案，还有必要进行研究。
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作者:admin@医学,生命科学 2011-09-07 05:12
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