主页 > 医学动态 >
【文摘发布】肝移植抗体诱导的作用
Author：Eason, James D
Source：Current Opinion in Organ Transplantation. 12(3):242-244, June 2007.
Abstract：Purpose: Antilymphocyte antibody induction has been used in liver transplantation for decades, initially as part of a triple or quadruple immunosuppressive protocol to prevent rejection or in the treatment of steroid-resistant rejection. More recently there has been renewed interest in antibody induction in liver transplantation as part of a strategy to eliminate or reduce one or more immunosuppressive agents. This review highlights recent advances in the role of antibody induction in liver transplantation.
Recent findings: Primary interest in antibody induction now falls into four major categories: steroid avoidance; calcineurin inhibitor reduction as a renal sparing protocol; minimal immunosuppression protocols (tolerance); and limiting hepatitis C recurrence. These protocols usually involve short courses of antibody induction in the peritransplant period, with decreased reliance on other agents after transplantation. Recent reports demonstrate several beneficial effects of antibody induction and suggest that, in the Model for End-Stage Liver Disease era, antibody induction in immunosuppressive strategies in liver transplantation will become increasingly important.
Summary: Antibody induction in liver transplantation confers valuable benefit in limiting the adverse effects of maintenance immunosuppression. Antibodies allow the subsequent reduction or elimination of other agents to minimize overall immunosuppression. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title：The role of antibody induction in liver transplantation
题目：抗体诱导在肝移植中的作用
Author：Eason, James D
作者：Eason, James D
Source：Current Opinion in Organ Transplantation. 12(3):242-244, June 2007.
来源：Current Opinion in Organ Transplantation. 12(3):242-244, June 2007.
Abstract：Purpose: Antilymphocyte antibody induction has been used in liver transplantation for decades, initially as part of a triple or quadruple immunosuppressive protocol to prevent rejection or in the treatment of steroid-resistant rejection.
摘要：目的：抗淋巴细胞抗体诱导已经应用于肝脏移植达数十年，最初作为三联或四联免疫抑制疗法的一部分，用来预防排斥反应或抗类固醇排斥反应的治疗。
More recently there has been renewed interest in antibody induction in liver transplantation as part of a strategy to eliminate or reduce one or more immunosuppressive agents. This review highlights recent advances in the role of antibody induction in liver transplantation.
前不久，人们开始重新关注于抗体诱导在肝移植方面的应用，将其作为消除或减少一种或多种免疫抑制药物的治疗方案的一部分。这篇综述特别强调了近来抗体诱导在肝移植中作用的研究进展。
Recent findings: Primary interest in antibody induction now falls into four major categories: steroid avoidance; calcineurin inhibitor reduction as a renal sparing protocol; minimal immunosuppression protocols (tolerance); and limiting hepatitis C recurrence.
最近的发现：抗体诱导的主要益处现在可以分成四类：避免类固醇的使用；减少钙调磷酸酶抑制剂的剂量，作为一种肾保护性方案；获得最低限度的免疫抑制方案（耐受）；限制丙型肝炎复发。
These protocols usually involve short courses of antibody induction in the peritransplant period, with decreased reliance on other agents after transplantation. Recent reports demonstrate several beneficial effects of antibody induction and suggest that, in the Model for End-Stage Liver Disease era, antibody induction in immunosuppressive strategies in liver transplantation will become increasingly important.
这些方案常包括肝移植围手术期的短期抗体诱导，减少移植术后对其他药剂的依赖。最近的报道证实了抗体诱导的一些有益的作用，并指出：在终末期肝病模型中，抗体诱导在肝移植的免疫抑制策略中将越来越重要。
Summary: Antibody induction in liver transplantation confers valuable benefit in limiting the adverse effects of maintenance immunosuppression. Antibodies allow the subsequent reduction or elimination of other agents to minimize overall immunosuppression.
总结：在肝脏移植中应用抗体诱导技术，能够有效降低因持续免疫抑制而带来的不良反应。 这些诱导的抗体从而能够减少或避免其他的药物的应用，从而降低总的免疫抑制程度。
编译：
题目：抗体诱导在肝移植中的作用
作者：Eason, James D
来源：Current Opinion in Organ Transplantation. 12(3):242-244, June 2007.
摘要：
目的：抗淋巴细胞抗体诱导已经应用于肝脏移植领域达数十年之久，最初被用做三联或者四联免疫抑制疗法的用药之一，用来预防移植排斥反应，或用于移植抗类固醇排斥反应（耐激素的排斥反应）的治疗。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-09-07 17:11
医学,生命科学网