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【medical-news】无症状性不孕症患者子宫内膜常出
NEW YORK (Reuters Health) Jan 15 - In nonpregnant women with asymptomatic bacterial vaginosis (BV), researchers observed a "modest, but impressively consistent" association between BV and colonization of the endometrium with BV-associated microorganisms.
However, in contrast to symptomatic BV, asymptomatic BV was not associated with plasma cell endometritis, report Dr. William W. Andrews and colleagues from the University of Alabama at Birmingham.
The researchers analyzed microbial cultures performed on endometrial specimens obtained from 769 women who experienced preterm delivery and were evaluated roughly 3 months' postpartum. Four hundred eight two women had endometrial specimens sufficient for histopathologic study as well.
Endometrial cultures were positive for at least 1 microorganisms in 83% of the women and plasma cell endometritis was seen in 39% of women, according to a report of the study in the American Journal of Obstetrics and Gynecology for December.
The frequency of positive endometrial cultures was only slightly higher among women with BV compared with women without BV and there was no association between BV and plasma cell endometritis, as mentioned.
What was "striking," according to Dr. Andrews and colleagues, was the "consistent and statistically significant association between BV ... and the likelihood of a positive endometrial culture for BV-associated bacteria defined and grouped in a variety of ways."
These observations, the researchers say, raise a number of questions. "Is the observed association between BV and upper tract colonization sufficient to explain the association between BV and spontaneous preterm birth or other adverse outcomes? Are these so-called BV-associated bacteria sufficiently virulent to cause spontaneous preterm birth when present only in modest increased frequency?"
"Does the observation that the association between BV and endometrial microbial colonization is only modest at best explain why the association between BV and preterm birth also is relatively modest, albeit a consistent observation?"
"More likely the relationships are simply more complex than our current understanding," Dr. Andrews and colleagues conclude.
Am J Obstet Gynecol 2006;195:1611-1616.
http://www.medscape.com/viewarticle/550803 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 无症状细菌性阴道病患者子宫内膜通常发现细菌性阴道病相关细菌
纽约（路透社）1月15日-在患有无症状细菌性阴道病（BV）的非孕妇女中，研究者们发现BV相关性细菌在子宫内膜的定居和BV有一定的联系。
来自伯明翰的阿拉巴马大学的William W. Andrews博士及其同事的报道指出，与有症状的BV相比，无症状性BV和浆细胞性子宫内膜炎并没有关联。
研究者们分析了用来自769个早产妇女的子宫内膜样本进行的细菌培养，并在产后进行3个月左右的评估。此外另有482位妇女的子宫内膜样本，足以用于进行组织病理学的研究。
根据12月份的美国妇产科学杂志的关于该研究的报道，83％的妇女子宫内膜培养结果为阳性，至少为一种微生物。39％的妇女检测出浆细胞性子宫内膜炎。
他们提到，BV患者的子宫内膜培养阳性率相比非BV患者仅轻微升高，且BV和浆细胞性子宫内膜炎之间无联系。
让人吃惊的是，根据Andrews博士及其同事，BV和BV相关性细菌的以一定方式成簇定居导致子宫内膜培养阳性率之间的关联有显著的统计学意义。
研究者表明，这些观察结果提出了一系列问题。已观察到的BV和其细菌上游定居之间的联系，是否足以解释BV和自发性早产或其他不利结果之间的联系？这些所谓的BV相关细菌当阳性率轻度升高后是否足以导致自发性早产？
所观察到的BV和子宫内膜微生物的定居间的联系不甚紧密是否正好说明了为什么BV和早产关系亦不明显，尽管存在？
Andrews博士和他同事总结说，很可能它们之间的联系比我们目前的了解更复杂。
美国妇产科学杂志2006；195：1611-1616. 翻译的比较仓促，呵呵，不妥还望指教。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-09-17 06:33
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