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【文摘发布范例】高胆固醇水平是痴呆的危险因
Author：Solomon A, Kareholt I, Ngandu T, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M.
Resource: Neurology. 2007 Mar 6;68(10):751-6
Abstract：BACKGROUND: Longitudinal studies have shown that high serum total cholesterol (TC) at midlife is a risk factor for dementia/Alzheimer disease. The significance of TC later in life is unclear. OBJECTIVE: To investigate changes in serum TC from midlife to late life and their relationship with late-life cognition. METHODS: Participants of the Cardiovascular Risk Factors, Aging and Dementia study were derived from random, population-based samples previously studied in a survey in 1972, 1977, 1982, or 1987. After an average follow-up of 21 years, 1,449 individuals aged 65 to 79 were reexamined in 1998. RESULTS: Serum TC levels decreased in most individuals. High midlife TC represented a risk factor for more severe cognitive impairment later in life, and the values were significantly different between the control, mild cognitive impairment, and dementia groups. There were no significant differences in serum TC at reexamination. A moderate decrease in serum TC from midlife to late life (0.5 to 2 mmol/L) was significantly associated with the risk of a more impaired late-life cognitive status, even after adjusting for age, follow-up time, sex, years of formal education, midlife cholesterol, changes in body mass index, APOE epsilon4 genotype, history of myocardial infarction/stroke/diabetes, and lipid-lowering treatment. CONCLUSIONS: The relationship between serum total cholesterol (TC) and dementia seems to be bidirectional. High midlife serum TC is a risk factor for subsequent dementia/Alzheimer disease, but decreasing serum TC after midlife may reflect ongoing disease processes and may represent a risk marker for late-life cognitive impairment.
PMID: 17339582 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 文题：中年后血清胆固醇水平的变化与老年认知功能的关系：随访21年的研究
作者：Solomon A, Kareholt I, Ngandu T, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M.
出处：Neurology. 2007 Mar 6;68(10):751-6
摘要：背景：纵向研究显示中年时高总胆固醇血症是患老年痴呆的危险因子，而中年以后血清总胆固醇水平的意义尚不清除。目的：研究中年到晚年血清总胆固醇水平所发生的变化，以及这种变化与老年认知功能之间的关系。方法：1972，1977，1982和1987年对心血管危险因子、衰老和老年痴呆研究中来自人群的随机样本作为本研究的受试者，平均随访21年后，受试者年龄为65－79岁，于1998年对1449名受试者进行复查。结果：大多数受试者血清总胆固醇水平降低。中年时高总胆固醇血症是老年时发生更严重认知功能障碍的危险因子，并且中年时血清总胆固醇水平在正常对照组、轻微认知功能障碍组和老年痴呆组间有显著差异，但复查时各组间血清总胆固醇水平无显著差异。从中年到老年血清总胆固醇水平的适度降低（降低0.5－2mmol/L）与老年认知功能受损风险的增加显著相关，这种关系既便是在校正了年龄、随访时间、性别、受正式教育时间、中年时胆固醇水平、体重指数的改变、载脂蛋白Eε4基因型、心肌梗死病史、卒中病史、糖尿病病史和降脂治疗后仍然成立。结论：血清总胆固醇水平与老年痴呆的关系似乎是双向影响的。中年时高总胆固醇血症是发生老年痴呆的危险因子，但中年后血清总胆固醇水平的适度降低可能反应了正在发展的疾病过程，这可能是发生老年认知功能受损的危险因子。
PMID: 17339582 提个建议
能不能在翻译了之后，把内容再编译成新闻稿的形式，让斑竹再拿去投稿，这就更有意思点 提个建议，如果方便的话可以把文章以附件的形式发上来，这样可以使感兴趣的战友下载，当然如果太大了，或者不方便弄到全文不发也可以 另外在文摘发布时能够加上分类，如分泌或者药剂等等，便于战友观看和认领
super19830102 wrote:
提个建议，如果方便的话可以把文章以附件的形式发上来，这样可以使感兴趣的战友下载，当然如果太大了，或者不方便弄到全文不发也可以
文章很好~如果有全文就更好了!!!!!!!!!! [标签:content1][标签:content2]阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-08-31 05:16
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