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【drug-news】Topiramate与2型糖尿病:老药新用
Topiramate and Type 2 diabetes: an old wine in a new bottle.Khanna V, Arumugam S, Roy S, Mittra S, Bansal VS.
Ranbaxy Research Laboratories, Department of Pharmacology, New Drug Discovery Research, R&D III, Plot No. 20, Sector 18, Udyog Vihar Industrial Area, Gurgaon-122015, Haryana, India +91 124 5012501 ext. 5266 ; +91 124 2343545 ; vivek.khanna@ranbaxy.com , *Both Authors Contributed equally.
Topiramate, a marketed antiepileptic drug, has been used to treat seizures and allied neurological problems since 1999. Recently, a series of newer findings for the use of topiramate have cropped up, which include Type 2 diabetes and obesity. In a series of clinical studies, a subset of neurological patients with Type 2 diabetes mellitus (T2DM) serendipitously showed better glycaemic control when treated with topiramate. It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models. Pathogenesis of Type 2 diabetes involves both beta-cell dysfunction and insulin resistance. Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM. Topiramate seems to act through multiple mechanisms to ameliorate diabetic symptoms, some of them unknown. Hence, it becomes imperative to discuss its probable modes of action. Topiramate raises new hope as an antidiabetic agent or a potential new chemotype with a better safety profile for the treatment of T2DM.
PMID: 18076372 [PubMed - as supplied by publisher] 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 1: Expert Opin Ther Targets. 2008 Jan;12(1):81-90. Links
Topiramate and Type 2 diabetes: an old wine in a new bottle.Khanna V, Arumugam S, Roy S, Mittra S, Bansal VS.
Ranbaxy Research Laboratories, Department of Pharmacology, New Drug Discovery Research, R&D III, Plot No. 20, Sector 18, Udyog Vihar Industrial Area, Gurgaon-122015, Haryana, India +91 124 5012501 ext. 5266 ; +91 124 2343545 ; vivek.khanna@ranbaxy.com , *Both Authors Contributed equally.
托吡酯与2型糖尿病：老药新用
作者：Khanna V, Arumugam S, Roy S, Mittra S, Bansal VS
印度Haryana ，Gurgaon-122015， Udyog Vihar工业区，18区20号，Ranbaxy研究室，药理部，新药研发III部。
Topiramate, a marketed antiepileptic drug, has been used to treat seizures and allied neurological problems since 1999. Recently, a series of newer findings for the use of topiramate have cropped up, which include Type 2 diabetes and obesity. In a series of clinical studies, a subset of neurological patients with Type 2 diabetes mellitus (T2DM) serendipitously showed better glycaemic control when treated with topiramate. It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models. Pathogenesis of Type 2 diabetes involves both beta-cell dysfunction and insulin resistance. Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM. Topiramate seems to act through multiple mechanisms to ameliorate diabetic symptoms, some of them unknown. Hence, it becomes imperative to discuss its probable modes of action. Topiramate raises new hope as an antidiabetic agent or a potential new chemotype with a better safety profile for the treatment of T2DM.
自1999年以来，抗癫痫药托吡酯一直用于治疗癫痫发作及相关的神经性疾病。目前，研究人员获得关于托吡酯新适应症的一些研究结果，其中包括2型糖尿病和肥胖症。在一系列的临床研究中，当用托吡酯治疗一组有2型糖尿病（T2DM）的神经疾病患者时意外发现，其对血糖有较好的控制。这说明在T2DM动物模型中，托吡酯同时有胰岛素促泌剂和胰岛素增敏剂作用。2型糖尿病包括β细胞功能障碍和胰岛素抵抗。所以，有此双重作用（胰岛素促泌及增敏）的药物适用于T2DM。托吡酯似乎通过多种作用机制改善糖尿病综合征，其中某些机制尚不清楚。因此，迫切需要对其可能的作用方式进行研究讨论。作为一种抗糖尿病药或者更安全的T2DM治疗药，托吡酯给人们带来了新的希望。
PMID: 18076372 [PubMed - as supplied by publisher] 编译：（中文字符：384）
印度研究人员发现，抗癫痫药托吡酯对2型糖尿病有良好作用效果。（Expert Opin Ther Targets. 2008 Jan;12(1):81-90）
自1999年以来，抗癫痫药托吡酯一直用于治疗癫痫发作及相关的神经性疾病。目前，研究人员获得关于托吡酯新适应症的一些研究结果，其中包括2型糖尿病和肥胖症。在一系列的临床研究中，当用托吡酯治疗一组有2型糖尿病（T2DM）的神经疾病患者时意外发现，其对血糖有较好的控制。这说明在T2DM动物模型中，托吡酯同时有促胰岛素分泌和胰岛素增敏作用。2型糖尿病包括β细胞功能障碍和胰岛素抵抗。所以，有此双重作用（胰岛素促泌及增敏）的药物适用于T2DM。托吡酯似乎通过多种作用机制改善糖尿病综合征，其中某些机制尚不清楚。因此，迫切需要对其可能的作用方式进行讨论研究。作为一种抗糖尿病药或者更安全的T2DM治疗药，托吡酯给人们带来了新的希望。（丁香） [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-08-28 08:09
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