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【J Neurosci】多巴胺和去甲肾上腺素在学习过程中
Liselijn A. B. Wisman, Gurdal Sahin, Matthew Maingay, Giampiero Leanza, and Deniz Kirik
(see pages 7797–7807)
This week, Wisman et al. describe interactions between dopaminergic and cholinergic pathways in modulating spatial memory. The authors used selective neurotoxins to lesion mesocorticolimbic dopaminergic neurons in the ventral tegmental area (VTA), septohippocampal cholinergic neurons in the medial septum, and/or basalocortical cholinergic neurons in the nucleus basalis magnocellularis. They then tested various forms of spatial learning using Morris water maze tasks. Reference memory—in which rats learned over several days to use extramaze navigational cues to find a stationary platform—was disrupted by dopaminergic lesions, but unaffected by cholinergic lesions. In contrast, performance on a working memory task—in which rats had to relearn the position of a platform that was moved daily—was not disrupted by dopamine or cholinergic lesions alone, but was disrupted when dopaminergic lesions were paired with septohippocampal cholinergic lesions. The results suggest that loss of dopaminergic neurons in the VTA contribute to cognitive decline in Parkinson's disease patients.
http://www.jneurosci.org/cgi/content/full/28/31/i 编译：
本周，Wisman等人撰文描述了多巴胺能和胆碱能通路在空间记忆中的调节作用。作者使用选择性的神经毒素损伤中脑边缘腹侧被盖区（VTA）的多巴胺能神经元，海马内侧隔核的胆碱能神经元和/或基底核基地大细胞中的基底皮质胆碱能神经元。研究者利用Morris水迷宫测试不同的空间学习形式。参考记忆，即试验鼠通过几天利用外部迷宫导航器搜寻水下平台的学习产生的记忆，在多巴胺能通路受损时遭到破坏，但在胆碱能通路异常时却未受影响。与此相反，工作记忆的执行能力，即每日移动试验鼠已经学习记忆的水下平台的一种测试，不会在单独多巴胺能通路或者胆碱能通路损伤时遭到破坏，而是在多巴胺能通路损伤伴随海马隔核胆碱能神经元损伤时出现异常。研究结果说明VTA多巴胺能神经元的丢失导致PD患者认知功能下降。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-06-22 05:15
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