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【medical-news】锌转运基因 SLC30A8 变异：与肾移植
Objective: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients, and insulin secretory defects play an important role in the pathogenesis of PTDM. The R325W (rs13266634) nonsynonymous polymorphism in the islet-specific zinc transporter protein gene, SLC30A8, has been reported to be associated with type 2 diabetes and possibly with a defect in insulin secretion. This study investigated the association between genetic variations in the SLC30A8 and PTDM in renal allograft recipients.
Research Design and Methods: A total of 624 unrelated renal allograft recipients without previously diagnosed diabetes were enrolled. Rs13266634 was genotyped in the cohort, which consisted of 174 PTDM patients and 450 non-PTDM subjects. The genotyping of the SLC30A8 polymorphism was performed using real-time PCR.
Results: The prevalence of PTDM was 33.8% in patients carrying the R/R genotype, 26.8% in patients with the R/W genotype, and 19.8% in patients with the W/W genotype. There was a strong association between the number of W alleles and PTDM risk reduction (p for trend=0.007). Patients with at least one T allele showed a decreased risk of PTDM compared to those with the R/R genotype (R/W; risk ratio=0.78, p=0.126, W/W; risk ratio= 0.52, p=0.007). The effect of the SLC30A8 genotype remained significant after adjustments for age, gender, body weight gain, and type of immunosuppressant (R/W; hazard ratio=0.77, p=0.114, W/W; hazard ratio=0.58, p=0.026).
Conclusions: These data provide evidence that the SLC30A8 rs13266634 gene variation is associated with protection from the development of PTDM in renal allograft recipients.
http://diabetes.diabetesjournals.org/cgi/content/abstract/db07-0761v3
作者单位
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
2Institute of Endocrine Research, Yonsei University College of Medicine, Seoul, Korea
3Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
4Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
5The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea
6Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea
7Department of Preventive Medicine and Public Health, Yonsei University College of Medicine, Seoul, Korea 我自己认领 过48小时了 ，我帮胭脂贴一下。请指正。
A Polymorphism in the Zinc Transporter Gene, SLC30A8, Confers Resistance Against Posttransplantation Diabetes Mellitus in Renal Allograft Recipients
锌离子转运基因， SLC308基因多态性，与肾移植术后的糖尿病有关。
Objective: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients, and insulin secretory defects play an important role in the pathogenesis of PTDM. The R325W (rs13266634) nonsynonymous polymorphism in the islet-specific zinc transporter protein gene, SLC30A8, has been reported to be associated with type 2 diabetes and possibly with a defect in insulin secretion. This study investigated the association between genetic variations in the SLC30A8 and PTDM in renal allograft recipients.
目的：肾移植后糖尿病（PTDM）是肾移植患者最主要的代谢并发症，PTDM的主要发病机理是胰岛素分泌减少。据报道，R325W (rs13266634)不同的多态性，位于胰岛上锌转运蛋白基因位点SLC30A8上，与II型糖尿病，胰岛素分泌减少有关。该向研究调查了SLC30A8遗传多态性和PTDM之间的相关性。
Research Design and Methods: A total of 624 unrelated renal allograft recipients without previously diagnosed diabetes were enrolled. Rs13266634 was genotyped in the cohort, which consisted of 174 PTDM patients and 450 non-PTDM subjects. The genotyping of the SLC30A8 polymorphism was performed using real-time PCR.
研究设计与方法：一共有624名没有糖尿病的肾脏移植者参加。在该研究中，Rs13266634是174名PTDM患者和450名非PTDM患者共有的基因型。用real-time PCR方法验证控制SLC30A8多态性的基因是有表达的。
Results: The prevalence of PTDM was 33.8% in patients carrying the R/R genotype, 26.8% in patients with the R/W genotype, and 19.8% in patients with the W/W genotype. There was a strong association between the number of W alleles and PTDM risk reduction (p for trend=0.007). Patients with at least one T allele showed a decreased risk of PTDM compared to those with the R/R genotype (R/W; risk ratio=0.78, p=0.126, W/W; risk ratio= 0.52, p=0.007). The effect of the SLC30A8 genotype remained significant after adjustments for age, gender, body weight gain, and type of immunosuppressant (R/W; hazard ratio=0.77, p=0.114, W/W; hazard ratio=0.58, p=0.026).
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作者:admin@医学,生命科学 2011-06-16 05:14
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