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【文摘发布】抑半胱氨酸蛋白酶蛋白C与内科医师
Volume 155, Issue 1, January 2008, Pages 82-86
Cystatin C and risk of heart failure in the Physicians' Health Study (PHS)
Luc Djoussé MD, MPH, DSca, , , Tobias Kurth MD, ScDa, b and J. Michael Gaziano MD, MPHa, b
aDepartment of Medicine, Division of Aging, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
bDepartment of Medicine, Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Received 12 June 2007; accepted 24 August 2007. Available online 17 October 2007.
Background
Chronic kidney disease is a risk factor for heart failure (HF). Although cystatin C can detect early kidney dysfunction, limited data are available on the association between cystatin C and HF.
Methods
In a prospective nested case-control study design, we examined whether cystatin C is associated with an increased risk of HF in the PHS and whether such an association is stronger in hypertensive subjects. We selected 220 cases of incident HF and 220 controls, matched on age, year of birth, and time of blood collection. Plasma cystatin C was measured using an immunonephelometry method. We used conditional logistic regression to estimate relative risks (RRs).
Results
Compared with the lowest tertile, the multivariable adjusted RR (95% CI) for HF was 1.15 (0.69-1.89) and 1.78 (1.01-3.13) for the second and third tertiles of cystatin C, respectively. Additional adjustment for systolic blood pressure and history of hypertension attenuated this association (RR = 1.0, 1.23 [0.73-2.09], and 1.61 [0.90-2.88] from the lowest to the highest tertile, respectively). Furthermore, we observed a 4-fold increased risk of HF in the second and third tertiles of cystatin C among hypertensive individuals and no meaningful effects of cystatin C on HF among nonhypertensive subjects.
Conclusions
Our data demonstrated that higher levels of cystatin C are associated with an increased risk of HF and that such association may be limited to hypertensive individuals. Additional studies are warranted to further examine the relationship between hypertension and cystatin C on the risk of HF.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9H-4PXG7MC-7&_user=10&_coverDate=01%2F31%2F2008&_rdoc=18&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236683%232008%23998449998%23676471%23FLA%23display%23Volume)&_cdi=6683&_sort=d&_docanchor=&_ct=37&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d20165c3bb8e671a48c0b5cf14ef7d02 Cystatin C and risk of heart failure in the Physicians' Health Study (PHS)
抑半胱氨酸蛋白酶蛋白C与内科医师健康研究中心力衰竭的关系
Background
背景：
Chronic kidney disease is a risk factor for heart failure (HF). Although cystatin C can detect early kidney dysfunction, limited data are available on the association between cystatin C and HF.
慢性肾脏疾病是心力衰竭（HF）危险因子。虽然抑半胱氨酸蛋白酶蛋白C可以检测早期肾功能不全，但关于抑半胱氨酸蛋白酶蛋白C与HF关系的数据还很缺乏。
Methods
方法：
In a prospective nested case-control study design, we examined whether cystatin C is associated with an increased risk of HF in the PHS and whether such an association is stronger in hypertensive subjects. We selected 220 cases of incident HF and 220 controls, matched on age, year of birth, and time of blood collection. Plasma cystatin C was measured using an immunonephelometry method. We used conditional logistic regression to estimate relative risks (RRs).·
在一项前瞻性巢式病例对照研究中，我们探讨了抑半胱氨酸蛋白酶蛋白C是否与内科医师研究被研究者心力衰竭危险增加有关，在高血压患者中这一关系是否更强。我们选择了220，名发生过HF的患者和220名年龄、出生年、采血时间匹配的对照者。采用免疫比浊法测定血清抑半胱氨酸蛋白酶蛋白C水平。我们采用条件Logistic回归分析计算相对危险度。
Results
结果：
Compared with the lowest tertile, the multivariable adjusted RR (95% CI) for HF was 1.15 (0.69-1.89) and 1.78 (1.01-3.13) for the second and third tertiles of cystatin C, respectively. Additional adjustment for systolic blood pressure and history of hypertension attenuated this association (RR = 1.0, 1.23 [0.73-2.09], and 1.61 [0.90-2.88] from the lowest to the highest tertile, respectively). Furthermore, we observed a 4-fold increased risk of HF in the second and third tertiles of cystatin C among hypertensive individuals and no meaningful effects of cystatin C on HF among nonhypertensive subjects.
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作者:admin@医学,生命科学 2011-06-21 05:14
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