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【medical-news】孕期血糖中度升高：提示非GDA患者
ABSTRACT
Objective: To determine whether 1-hour oral glucose challenge test (OGCT) or 3-hour oral glucose tolerance test (OGTT) results below gestational diabetes criteria are associated with developing future diabetes.
Research Design and Methods: A retrospective cohort study was performed among women without gestational diabetes who had a pregnancy OGCT (N=24,780) or OGTT (N=6,222). The risk of subsequent diabetes was ascertained by ICD-9 codes, pharmacy or laboratory data over a median follow-up of 8.8 years.
Results: Future diabetes risk increased across OGCT quartiles: adjusted hazard ratio, HR, 1.67 (95%CI 1.07–2.61) for 5.4–6.2 mmol/l; 2.13 (95%CI 1.39–3.25) for 6.3–7.3 mmol/l; and 3.60 (95%CI 2.41–5.39) for 7.4 mmol/l compared to 5.3 mmol/l. Women with one abnormal OGTT result had a higher risk compared to those with normal values (adjusted HR, 2.08, 95%CI 1.35–3.20).
Conclusions: Women with modestly elevated glucose levels below the threshold for gestational diabetes had a higher risk of future diabetes.
http://care.diabetesjournals.org/cgi/content/abstract/dc07-1957v1
作者单位
1Obstetrics & Gynecology, University of Washington
2the Group Health Center for Health Studies
3Epidemiology
4University of Washington, the Division of Metabolism, Endocrinology, and Nutrition, VA Puget Sound Health Care System and the University of Washington
5and Cardiovascular Health Research Unit, Seattle, WA [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-07 18:15
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