主页 > 医学动态 >
【drug-news】研究显示睾酮的治疗获益不确定
Main Category: Men's health News
Article Date: 11 Jan 2007 - 13:00 PST
Little research exists demonstrating that testosterone is both safe from the cardiovascular standpoint and effective to treat sexual dysfunction, reveal Mayo Clinic researchers in two new studies.
In articles published in the January issue of Mayo Clinic Proceedings, Mayo Clinic physicians call for large studies to help clinicians and patients make informed decisions about when testosterone should be prescribed.
"One of the initial surprises is how limited the research evidence is regarding whether testosterone is an effective treatment for sexual dysfunction while being safe from the cardiovascular disease standpoint," says Victor M. Montori, M.D., MSc, lead researcher for Mayo Clinic's Knowledge and Encounter Research Unit, and an author of the two studies in Mayo Clinic Proceedings. "There is no way for physicians to be certain when prescribing testosterone that, on average, it's doing more good than harm."
Both studies involved review and meta-analysis of randomized trials to assess the effect of testosterone on sexual dysfunction and cardiovascular events. Authors determined that no strong evidence exists showing testosterone doesn't cause cardiovascular harm and results regarding its impact on sexual dysfunction are inconsistent.
In 2004, the Endocrine Society established a task force to generate evidence-based guidelines about the use of testosterone in treating men. Dr. Montori says Mayo researchers joined the effort in order to help the Endocrine Society provide recommendations based on up-to-date research.
"We found that the evidence for whether men are better off being treated with testosterone is much weaker than the evidence for giving estrogen to post-menopausal women was before the big estrogen trials came out," Dr. Montori says.
Despite the weak evidence supporting testosterone's efficacy, drug companies have successfully driven its sale, Dr. Montori says. Currently, physicians may be prescribing testosterone to otherwise healthy men who report poor quality of life, limited sex drive and fatigue and may have somewhat low testosterone levels.
These clinicians and their patients will be "thoroughly shocked" to discover the limited evidence supporting the drug's effectiveness in treating sexual dysfunction and the limited data supporting its cardiovascular safety, Dr. Montori says. "Researchers should conduct trials measuring the outcomes of testosterone treatment that are important to patients in order to avoid repeating the estrogen disaster," he says.
http://www.medicalnewstoday.com/medicalnews.php?newsid=60493 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Benefits Of Testosterone Treatment Unknown, Research Shows
研究显示睾酮治疗获益尚不确切
Main Category: Men's health News
类别：男性健康
Article Date: 11 Jan 2007 - 13:00 PST
文章日期：2007年1月11-13：00
Little research exists demonstrating that testosterone is both safe from the cardiovascular standpoint and effective to treat sexual dysfunction, reveal Mayo Clinic researchers in two new studies.
几乎没有研究成果证实睾酮在维持心血管健康的安全性以及治疗性功能障碍的有效性。
In articles published in the January issue of Mayo Clinic Proceedings, Mayo Clinic physicians call for large studies to help clinicians and patients make informed decisions about when testosterone should be prescribed.
文章出版在美国梅约医学中心《梅约临床进展杂志 》，梅约医学中心专家呼吁进行大规模的研究以帮助临床医生和病人确定睾酮该什么情况下给药。
"One of the initial surprises is how limited the research evidence is regarding whether testosterone is an effective treatment for sexual dysfunction while being safe from the cardiovascular disease standpoint," says Victor M. Montori, M.D., MSc, lead researcher for Mayo Clinic's Knowledge and Encounter Research Unit, and an author of the two studies in Mayo Clinic Proceedings. "There is no way for physicians to be certain when prescribing testosterone that, on average, it's doing more good than harm."
一种令人吃惊的结果是睾酮在治疗性功能障碍上是否有效证据是如此之少；并且在维持心血管健康上证据也相当匮乏。Victor M. Montori教授指出：正常情况下，医生根本没有办法确认给药睾酮的疗效大于其危害。
Both studies involved review and meta-analysis of randomized trials to assess the effect of testosterone on sexual dysfunction and cardiovascular events. Authors determined that no strong evidence exists showing testosterone doesn't cause cardiovascular harm and results regarding its impact on sexual dysfunction are inconsistent.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-03-27 17:11
医学,生命科学网