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【medical-news】科学家发现促使癌症扩散的基因
Scientists find a gene that makes cancer spread
CHICAGO (Reuters) – A single gene appears to play a crucial role in deadly breast cancers, increasing the chances the cancer will spread and making it resistant to chemotherapy, U.S. researchers said on Monday.
They found people with aggressive breast cancers have abnormal genetic alterations in a gene called MTDH, and drugs that block the gene could keep local tumors from metastasizing or spreading, increasing a woman's chances for survival.
"Not only has a new metastasis gene been identified, but this also is one of a few such genes for which the exact mode of action has been elucidated," said Dr. Michael Reiss of The Cancer Institute of New Jersey in New Brunswick, whose study appears in the journal Cancer Cell.
"That gives us a real shot at developing a drug that will inhibit metastasis," he said in a statement.
Stopping cancer's spread is important -- while more than 98 percent of patients with breast cancer that has not spread live five years or more, only 27 percent of patients whose cancer has spread to other organs survive.
Reiss and Yibin Kang of Princeton University used several different research approaches to find the gene, which helps tumor cells stick to blood vessels in distant organs. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Scientists find a gene that makes cancer spread
科学家们发现了促使癌症扩散的基因
CHICAGO (Reuters) – A single gene appears to play a crucial role in deadly breast cancers, increasing the chances the cancer will spread and making it resistant to chemotherapy, U.S. researchers said on Monday.
芝加哥（路透社）-美国研究者星期一说：他们发现了一个基因，该基因可增加乳腺癌细胞扩散机会和使其对化疗耐药，从而在致死性乳腺癌中似乎起着重要作用。
They found people with aggressive breast cancers have abnormal genetic alterations in a gene called MTDH, and drugs that block the gene could keep local tumors from metastasizing or spreading, increasing a woman's chances for survival.
他们研究发现侵袭性乳腺癌病人中存在一个名为MTDH基因的异常基因改变，而阻断该基因的药物能使肿瘤免于转移和扩散，这样可增加了女性病人生存的机会。
"Not only has a new metastasis gene been identified, but this also is one of a few such genes for which the exact mode of action has been elucidated," said Dr. Michael Reiss of The Cancer Institute of New Jersey in New Brunswick, whose study appears in the journal Cancer Cell.
新不伦瑞克的新泽西癌症研究所的Michael Reiss博士说道：“不仅可以鉴定一个新的转移基因，而且也能够阐明一些这样基因确切的作用方式。”该研究结果发表于《癌症细胞》杂志上。
"That gives us a real shot at developing a drug that will inhibit metastasis," he said in a statement.
他在陈述中说道：“这将使我们集中精力开发一种可抑制转移的药物。”
Stopping cancer's spread is important -- while more than 98 percent of patients with breast cancer that has not spread live five years or more, only 27 percent of patients whose cancer has spread to other organs survive.
终止癌症的扩散是重要——没有扩散的乳腺癌98%以上生存5年及以上者，而扩散到其他器官的乳腺癌病人仅27%生存。
Reiss and Yibin Kang of Princeton University used several different research approaches to find the gene, which helps tumor cells stick to blood vessels in distant organs.
Reiss 和 来自于普林斯通大学的Yibin Kang使用了不同的研究方法发现了这个基因，该基因有助于肿瘤细胞粘附于远处器官的血管。 科学家们发现了促使癌症扩散的基因
芝加哥（路透社）-美国研究者星期一说：他们发现了一个基因，该基因可增加乳腺癌细胞扩散机会和使其对化疗耐药，从而在致死性乳腺癌中似乎起着重要作用。
他们研究发现侵袭性乳腺癌病人中存在一个名为MTDH基因的异常基因改变，而阻断该基因的药物能使肿瘤免于转移和扩散，这样可增加了女性病人生存的机会。
新不伦瑞克的新泽西癌症研究所的Michael Reiss博士说道：“不仅可以鉴定一个新的转移基因，而且也能够阐明一些这样基因确切的作用方式。”该研究结果发表于《癌症细胞》杂志上。
他在陈述中说道：“这将使我们集中精力开发一种可抑制转移的药物。”
终止癌症的扩散是重要——没有扩散的乳腺癌98%以上生存5年及以上者，而扩散到其他器官的乳腺癌病人仅27%生存。
Reiss 和 来自于普林斯通大学的Yibin Kang使用了不同的研究方法发现了这个基因，该基因有助于肿瘤细胞粘附于远处器官的血管。 促使肿瘤转移的基因太多了，这样的研究稍显有点过于夸大其意义。
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作者:admin@医学,生命科学 2011-03-25 05:14
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