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【medical-news】肥胖儿童的脂肪肝发生率有所升高
Public release date: 15-Mar-2007
Incidence of Fatty Liver Disease rises as obesity in children increases
INDIANAPOLIS -- Indiana University School of Medicine researchers are taking a closer look at a disease whose incidence is rising as obesity in children increases. Non-Alcoholic Steatohepatitis, more popularly known as Fatty Liver Disease, occurs in approximately 15% of obese children. Fatty Liver Disease, in which fat accumulates in the liver, while not life threatening in children, can lead to cirrhosis (scarring) of the liver, sometimes requiring transplantation by adulthood.
"Until now the only treatment for Fatty Liver Disease has been to offer diet and exercise counseling, but this is often not effective. As part of a national multicenter research network, we are now looking at Vitamin E and at metformin, a drug used to treat Type II diabetes, as possible therapies" said Jean Molleston, M.D., clinical professor of pediatrics at IU School of Medicine and director of pediatric gastroenterology at Riley Hospital for Children. Dr. Molleston is the pediatric principal investigator for the IU School of Medicine site of TONIC, an eight-center Phase III study funded by the National Institute of Diabetes and Digestive and Kidney Disease, which is investigating treatment options for Fatty Liver Disease in 8 to 17 year olds and is the largest study of its type to date.
"We are seeing a growing number of young people with Fatty Liver Disease, and we need to tackle the disease before it becomes full blown in adulthood," said Dr. Molleston. "We routinely test children for conditions with much lower incidence such as scoliosis. Although we do not yet have formal guidelines for screening for Fatty Liver Disease, I personally think that all obese children should be screened for Fatty Liver Disease so we can intervene before it damages the liver."
A simple blood test to determine if liver enzyme levels are elevated alerts pediatricians that the child needs to be evaluated for Fatty Liver Disease.
Approximately a third of children and teens in the United States are overweight and 15% of children and teens are obese. Fatty Liver Disease may exist in 15% or more of obese children.
The American Liver Foundation estimates that 10-20% of Americans have Fatty Liver Disease. 本人认领此文。如在48小时内未能提交译文，其他战友可自由认领。 http://www.eurekalert.org/pub_releases/2007-03/iu-iof031507.php
Public release date: 15-Mar-2007
公开发行日期：2007年3月15日
Incidence of Fatty Liver Disease rises as obesity in children increases
肥胖儿童的脂肪肝发生率有所升高
INDIANAPOLIS -- Indiana University School of Medicine researchers are taking a closer look at a disease whose incidence is rising as obesity in children increases. Non-Alcoholic Steatohepatitis, more popularly known as Fatty Liver Disease, occurs in approximately 15% of obese children. Fatty Liver Disease, in which fat accumulates in the liver, while not life threatening in children, can lead to cirrhosis (scarring) of the liver, sometimes requiring transplantation by adulthood.
印第安纳波利斯——印第安纳大学医学院研究员对一种随着儿童肥胖度增加发生率升高的疾病进行了仔细的观察。非酒精性脂肪性肝，更普遍以脂肪肝著称，在极度肥胖的儿童中发生率大约15%。脂肪肝即脂肪在肝脏中积聚，儿时没有生命威胁，成年后可能导致肝硬化，有时还需要肝移植。
"Until now the only treatment for Fatty Liver Disease has been to offer diet and exercise counseling, but this is often not effective. As part of a national multicenter research network, we are now looking at Vitamin E and at metformin, a drug used to treat Type II diabetes, as possible therapies" said Jean Molleston, M.D., clinical professor of pediatrics at IU School of Medicine and director of pediatric gastroenterology at Riley Hospital for Children.
Dr. Molleston is the pediatric principal investigator for the IU School of Medicine site of TONIC, an eight-center Phase III study funded by the National Institute of Diabetes and Digestive and Kidney Disease, which is investigating treatment options for Fatty Liver Disease in 8 to 17 year olds and is the largest study of its type to date. 编译：
字数646
http://www.eurekalert.org/pub_releases/2007-03/iu-iof031507.php
公开发行日期：2007年3月15日
肥胖儿童的脂肪肝发生率有所升高
印第安纳波利斯——印第安纳大学医学院研究员对一种随着儿童肥胖度增加发生率升高的疾病进行了仔细的观察。非酒精性脂肪性肝，更普遍以脂肪肝著称，在极度肥胖的儿童中发生率大约15%。脂肪肝即脂肪在肝脏中积聚，儿时没有生命威胁，成年后可能导致肝硬化，有时还需要肝移植。
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作者:admin@医学,生命科学 2011-03-26 05:14
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