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【文摘发布】采用空气雾化喷嘴和大孔径微泵制
Author：A.M.A. Elhissia, M. Faizia, W.F. Najia, H.S. Gilla and K.M.G. Taylor
Resource: International Journal of Pharmaceutics ，334(1-2 ): 62-70
Abstract：
The aerosol properties of liposomes and their physical stability to aerosolization were evaluated using an air-jet nebulizer (Pari LC Plus) and a customized large aperture vibrating-mesh nebulizer (Aeroneb Pro-8 μm). Soya phosphatidylcholine: cholesterol (1:1 mole ratio) multilamellar liposomes (MLVs) entrapping salbutamol sulfate were nebulized directly, or after being reduced in size by extrusion through 1 or 0.4 μm polycarbonate membrane filters. MLVs were very unstable to jet nebulization and stability was not markedly enhanced when vesicles were extruded before nebulization, such that drug losses from delivered liposomes using the Pari nebulizer were up to 88% (i.e. only 12% retained in liposomes). The Aeroneb Pro-8 μm nebulizer was less disruptive to liposomes, completed nebulization in a much shorter time, and produced greater mass output rate than the Pari nebulizer. However, aerosol droplets were larger, total drug and mass outputs were lower and aerosolization performance was dependent on formulation. Vibrating-mesh nebulization was less disruptive to liposomes extruded through the 1 μm membranes compared with the non-extruded MLVs, so that the retained entrapment of the drug in the nebulized vesicles was 56% and 37%, respectively. However, extrusion of liposomes to 0.4 μm resulted in reduced stability of liposomes to vibrating-mesh nebulization (retained entrapment = 41%) which was attributed to the reduced liposome lamellarity and subsequent reduced resistance to nebulization-induced shearing. This study has shown that vibrating-mesh nebulization using the customized large aperture mesh nebulizer (Aeroneb Pro-8 μm) had a less disruptive effect on liposomes and produced a higher output rate compared with the Pari LC Plus air-jet nebulizer. On the other hand, the air-jet nebulizer produced higher total mass and drug outputs and smaller aerosol droplets.
PMID:17123757 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title：Physical stability and aerosol properties of liposomes delivered using an air-jet nebulizer and a novel micropump device with large mesh apertures
标题：采用空气雾化喷雾器和大孔径微泵制备脂质体并评价其物理稳定性及胶体特性
Author：A.M.A. Elhissia, M. Faizia, W.F. Najia, H.S. Gilla and K.M.G. Taylor
作者：A.M.A. Elhissia, M. Faizia, W.F. Najia, H.S. Gilla and K.M.G. Taylor
Resource: International Journal of Pharmaceutics ，334(1-2 ): 62-70
出处：国际制药学杂志，334(1-2 ): 62-70
Abstract：
摘要：
The aerosol properties of liposomes and their physical stability to aerosolization were evaluated using an air-jet nebulizer (Pari LC Plus) and a customized large aperture vibrating-mesh nebulizer (Aeroneb Pro-8 μm).
采用空气雾化喷雾器（Pari LC Plus）和一种定制的大孔径振动喷雾器（Aeroneb Pro-8 μm）制备脂质体，并对其胶体特性及雾化物理稳定性进行评价。
Soya phosphatidylcholine: cholesterol (1:1 mole ratio) multilamellar liposomes (MLVs) entrapping salbutamol sulfate were nebulized directly, or after being reduced in size by extrusion through 1 or 0.4 μm polycarbonate membrane filters.
用大豆磷脂：胆固醇（摩尔比1：1）的多层脂质体（MLVs）包裹硫酸沙丁胺醇使直接成雾状，或者通过1或0.4μm的聚碳酸酯滤膜喷雾以减小粒径。
MLVs were very unstable to jet nebulization and stability was not markedly enhanced when vesicles were extruded before nebulization, such that drug losses from delivered liposomes using the Pari nebulizer were up to 88% (i.e. only 12% retained in liposomes).
MLVs在喷雾过程中非常不稳定，而且即使在喷雾前逐出气泡也不能显著提高其稳定性，因此，通过采用Pari喷雾器制备脂质体的药物损失率可达到88％（也就是说，仅有12％留在脂质体中。）
The Aeroneb Pro-8 μm nebulizer was less disruptive to liposomes, completed nebulization in a much shorter time, and produced greater mass output rate than the Pari nebulizer.
Aeroneb Pro-8 μm 喷雾器对脂质体的破坏较小，整个喷雾过程在非常短的时间内完成，并且质量产率比Pari喷雾器高。
However, aerosol droplets were larger, total drug and mass outputs were lower and aerosolization performance was dependent on formulation.
然而，雾滴比较大，总的药品及质量产量比较低，并且雾化过程依赖于处方。
Vibrating-mesh nebulization was less disruptive to liposomes extruded through the 1 μm membranes compared with the non-extruded MLVs, so that the retained entrapment of the drug in the nebulized vesicles was 56% and 37%, respectively.
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作者:admin@医学,生命科学 2011-03-11 17:11
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