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【文摘发布】由口腔采样药签污染造成绿脓杆菌
Author: Bjørn G. Iversen,1 Trond Jacobsen,3 Hanne-Merete Eriksen,1 Geir Bukholm,4 Kjetil K. Melby,2 Karin Nygård,1 and Preben Aavitsland1
Resource: Clinical Infectious Diseases 2007;44:794-801
Background. Pseudomonas aeruginosa is an opportunistic bacterium that can cause severe infection in susceptible patients. During the winter of 2001–2002, we investigated an outbreak of P. aeruginosa infection among patients in several hospitals across Norway.
Methods. A nationwide outbreak investigation was performed with case finding, questionnaires, and product sampling. All available clinical and environmental P. aeruginosa strains were genotyped. Detailed information was collected from patients with the outbreak strain or with any P. aeruginosa in blood or cerebrospinal fluid samples. To identify risk factors, we conducted a case-control study among patients with P. aeruginosa isolated from blood or cerebrospinal fluid samples during October 2001–December 2002. Case patients were patients infected with the outbreak genotype, and control subjects were patients infected with other genotypes.
Results. A total of 231 patients from 24 hospitals were identified as having the outbreak strain; 39 of these patients had positive blood culture results. Seventy-one patients (31%) died while hospitalized; all of the patients who died had severe underlying disease. Among 39 case patients and 159 control subjects, use of the moist mouth swab (adjusted odds ratio, 5.3; 95% confidence interval, 2.0–13.6) and receipt of mechanical ventilation (adjusted odds ratio, 6.4; 95% confidence interval, 2.3–17.2) were associated with infection due to the outbreak strain. Genotypically identical strains of P. aeruginosa were identified in 76 mouth swabs from 12 different batches and from the production line.
Conclusions. Contamination of mouth swabs during production caused the largest-ever outbreak of P. aeruginosa infection in Norway. Susceptible patient groups should use only documented quality-controlled, high-level–disinfected products and items in the oropharynx. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title:An Outbreak of Pseudomonas aeruginosa Infection Caused by Contaminated Mouth Swabs 由
由口腔采样药签污染造成绿脓杆菌感染爆发
Author: Bjørn G. Iversen,1 Trond Jacobsen,3 Hanne-Merete Eriksen,1 Geir Bukholm,4 Kjetil K. Melby,2 Karin Nygård,1 and Preben Aavitsland1
Resource: Clinical Infectious Diseases 2007;44:794-801
来源:临床感染疾病2007;44:794-801
Background. Pseudomonas aeruginosa is an opportunistic bacterium that can cause severe infection in susceptible patients. During the winter of 2001–2002, we investigated an outbreak of P. aeruginosa infection among patients in several hospitals across Norway.
Methods. A nationwide outbreak investigation was performed with case finding, questionnaires, and product sampling. All available clinical and environmental P. aeruginosa strains were genotyped. Detailed information was collected from patients with the outbreak strain or with any P. aeruginosa in blood or cerebrospinal fluid samples. To identify risk factors, we conducted a case-control study among patients with P. aeruginosa isolated from blood or cerebrospinal fluid samples during October 2001–December 2002. Case patients were patients infected with the outbreak genotype, and control subjects were patients infected with other genotypes.
背景.铜绿假单胞菌是一种机会性致病菌在易感患者可引起严重感染.2001-2002年冬季,我们研究了挪威几家医院铜绿假单胞菌感染爆发情况.
方法.通过检出病例、问卷、产品抽样的方法调查全国爆发情况。所有临床和环境中采集到的都做基因型鉴定，具有导致爆发流行铜绿假单胞菌菌株的患者及血液或脑脊液样本中发现铜绿假单胞菌的患者的详细信息被收集。为确定风险因素，我们对2001年10月到2002年十二月间血液或脑脊液标本中分离到铜绿假单胞菌的患者进行病历对照分析，实验组为爆发流行菌株感染病人，对照组为其他菌株感染者。
Results. A total of 231 patients from 24 hospitals were identified as having the outbreak strain; 39 of these patients had positive blood culture results. Seventy-one patients (31%) died while hospitalized; all of the patients who died had severe underlying disease. Among 39 case patients and 159 control subjects, use of the moist mouth swab (adjusted odds ratio, 5.3; 95% confidence interval, 2.0–13.6) and receipt of mechanical ventilation (adjusted odds ratio, 6.4; 95% confidence interval, 2.3–17.2) were associated with infection due to the outbreak strain. Genotypically identical strains of P. aeruginosa were identified in 76 mouth swabs from 12 different batches and from the production line.
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作者:admin@医学,生命科学 2011-03-10 05:11
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