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【文摘发布】低氧诱导因子驱动血管重塑的细胞
Author: Hanze J,Weissmann N, Grimminger F, Seeger W, Rose F.
Resource: Thromb Haemost. 2007 May;97(5):774-87
Abstract: Hypoxia-inducible factor (HIF) is an oxygen-dependent transcription factor that activates a diverse set of target genes, the products of which are involved in adaptive processes to hypoxia. Employing genetic manipulation of HIF expression, in-vivo and cellular studies have focused on HIF as a crucial factor affecting hypoxia-induced vascular remodeling. Vascular remodeling comprises processes which establish and improve blood vessel supply such as vasculogenesis, angiogenesis and arteriogenesis. These processes are observed during ontogenesis, tumor progression, ischemic disease or physical training. Furthermore, under hypoxic conditions, a pulmonary-specific type of vascular remodeling called pulmonary arterial remodeling occurs that is characterized by thickening of the vessel wall with a concomitant reduction in the vessel lumen area, thereby limiting blood flow. This response results in pulmonary hypertension with right ventricular hypertrophy, a lethal disease. In this review, we summarize and discuss mechanisms by which HIF interferes with the different vascular remodeling processes.
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Title: Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling.
低氧诱导因子驱动血管重塑的细胞分子机制
Author: Hanze J,Weissmann N, Grimminger F, Seeger W, Rose F.
Resource: Thromb Haemost. 2007 May;97(5):774-87
Abstract: 摘要： Excellent job!!总体翻译得非常不错。只是注意以后翻译时，中心词定语不可太长，影响译文质量。可适当拆为几个句子。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-09 17:12
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