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【medical-news】奥司他韦在治疗甲类流行性感冒（
Author: de Jong, MD; Thanh, TT; Khanh, TH, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 353 Issue: 25 Pages: 2667-2672 Published: DEC 22 2005
Times Cited: 187
Influenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A ( H5N1) virus infection include additional antiviral agents. Title: Brief report - Oseltamivir resistance during treatment of influenza A (H5N1) infection
奥司他韦在治疗甲型流感（ H5N1 ）中出现耐药性
Author: de Jong, MD; Thanh, TT; Khanh, TH, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 353 Issue: 25 Pages: 2667-2672 Published: DEC 22 2005
Times Cited: 187
作者：de Jong, MD; Thanh, TT; Khanh, TH等
文章来源：新英格兰医学杂志,353卷,25期,2667-2672页；发表日期:2005年12月22日
Influenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A ( H5N1) virus infection include additional antiviral agents.
八名越南甲型流感患者接受奥司他韦治疗，从两名患者体内分离出的甲型流感（H5N1）病毒其神经氨酸酶上带有一个氨基酸基，对奥司他韦（oseltamivir）有较高的耐药性。虽然其中一名患者接受了早期治疗，但两人仍都死于甲型流感（H5N1）。治疗过程中，生存下来的患者其病毒载量迅速下降至检测限以下。观察结果说明，一般推荐的奥司他韦治疗会出现耐药性，而且可能会导致临床症状恶化，因此治疗甲型流感（H5N1）病毒感染需要加入其他抗病毒药物。（丁香）
编译：
八名越南患者感染甲型流感病毒，并接受奥司他韦治疗，其中两名患者死亡。从这两名患者体内分离出的甲型流感（H5N1）病毒的神经氨酸酶上带有一氨基酸基团，对奥司他韦（oseltamivir）有较高耐药性。治疗过程中，存活患者其病毒载量迅速下降至检测限以下。观察结果说明，一般推荐的奥司他韦治疗会出现耐药性，而且可能会导致临床症状恶化，因此治疗甲型流感（H5N1）病毒感染需要加入其他抗病毒药物。（丁香） [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-01 17:11
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