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【medical-news】多能人类干细胞系--帮助我们了解癌
Tamra E. Werbowetski-Ogilviea and Mickie Bhatiaa,
aMcMaster Stem Cell and Cancer Research Institute, 1200 Main St. West, Hamilton, Ontario L8N 3Z5, Canada
Available online 16 July 2008.
Although the cancer stem cell (CSC) hypothesis has become an attractive model to account for tumor recurrence, failure to define a cell of origin has created the need to explore alternative models for cancer initiation and maintenance. Recent studies have linked an embryonic stem cell (ESC)-like gene signature with poorly defined high-grade tumors. Here, we review advances in the ESC field with an emphasis on how human pluripotent stem cells (hPSCs) can be used to define early tumorigenic events, including potential miRNA and epigenetic targets, as well as proto-oncogene and tumor suppressor networks that might facilitate hierarchal transformation. These studies allow for investigation of cancer initiation in a manner that cannot be achieved using primary tumors, where only retrospective evaluation of CSC development is possible. By comparing transformed hPSCs with their normal counterparts, we hope to develop novel cell-specific therapies that selectively target CSCs.
Trends in Molecular Medicine
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W7J-4T0M622-2&_user=5341118&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050159&_version=1&_urlVersion=0&_userid=5341118&md5=be3cfdc178395172c25bb5d329b2b998 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Pluripotent human stem cell lines: what we can learn about cancer initiation
人多能性胚胎干细胞系:肿瘤发生的启示
Tamra E. Werbowetski-Ogilviea and Mickie Bhatiaa,
aMcMaster Stem Cell and Cancer Research Institute, 1200 Main St. West, Hamilton, Ontario L8N 3Z5, Canada
Available online 16 July 2008.
Although the cancer stem cell (CSC) hypothesis has become an attractive model to account for tumor recurrence, failure to define a cell of origin has created the need to explore alternative models for cancer initiation and maintenance. Recent studies have linked an embryonic stem cell (ESC)-like gene signature with poorly defined high-grade tumors.
尽管肿瘤干细胞假说已经成为一个很有吸引力的模型去解释肿瘤复发，但是解释不了细胞的来源就必须探究其他肿瘤发生和发展的模型。最近研究发现以前很难分清的高恶性度肿瘤与一个胚胎干细胞样基因标记有关。
Here, we review advances in the ESC field with an emphasis on how human pluripotent stem cells (hPSCs) can be used to define early tumorigenic events, including potential miRNA and epigenetic targets, as well as proto-oncogene and tumor suppressor networks that might facilitate hierarchal transformation.
这里我们综述了胚胎干细胞领域的相关进展，着重描述人多能性干细胞怎样才能用来说明早期的肿瘤发生，包括潜在的miRNA和印迹基因靶标，同时也介绍可促进层次转化的原癌基因和抑癌基因网络。
These studies allow for investigation of cancer initiation in a manner that cannot be achieved using primary tumors, where only retrospective evaluation of CSC development is possible. By comparing transformed hPSCs with their normal counterparts, we hope to develop novel cell-specific therapies that selectively target CSCs.
这些研究考虑到研究肿瘤发生不能以原有的肿瘤为研究对象，而只有通过追溯肿瘤干细胞的发生来分析才有可能了解它的发生。通过已经转化的hPSCs和正常对照，我们希望能够研究出新的选择性定向CSCs的细胞特异性治疗方法。
编译：
人多能性胚胎干细胞系:肿瘤发生的启示
尽管肿瘤干细胞假说已经成为一个很有吸引力的模型去解释肿瘤复发，但是解释不了细胞的来源就必须探究其他肿瘤发生和发展的模型。最近研究发现以前很难分清的高恶性度肿瘤与一个胚胎干细胞样基因标记有关。这里我们综述了胚胎干细胞领域的相关进展，着重描述人多能性干细胞怎样才能用来说明早期的肿瘤发生，包括潜在的miRNA和印迹基因靶标，同时也介绍可促进层次转化的原癌基因和抑癌基因网络。这些研究考虑到研究肿瘤发生不能以原有的肿瘤为研究对象，而只有通过追溯肿瘤干细胞的发生来分析才有可能了解它的发生。通过已经转化的hPSCs和正常对照，我们希望能够研究出新的选择性定向CSCs的细胞特异性治疗方法。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-10-19 17:52
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