主页 > 生命科学 >
【medical-news】眼组织的短缺将危及未来的临床研
Rockville, Md. − The future of clinical ophthalmology may be endangered by the decline in the number of human donor eyes provided by U.S. eye banks according to an article published in the July 2006 issue of Investigative Ophthalmology & Visual Science (IOVS).
According to a survey of U.S. members of the Association for Research in Vision and Ophthalmology (ARVO), the major prohibitory factor in the use of human eye tissue is lack of availability of tissue meeting stringent criteria. The survey's conductor, Christine A. Curcio, PhD, of ARVO's Research Tissue Acquisition Working Group (RTAWG), found that only cost exceeded this factor among those surveyed. Respondents also indicated that local eye banks are the most common tissue source although most investigators use multiple tissues sources, including remote eye banks to acquire adequate human eye tissue needed for research.
The availability of human eye tissue for research has been severely impacted by federal regulations and state laws enacted over the last decade, and some individual eye bank practices may be of importance on a local level (e.g., laws prohibiting medical examiners from releasing eye tissue in cases of violent or suspicious death).
The RTAWG believes that the decline in human research tissue may be managed in the short term by researchers working closely with eye banks and other providers, communicating on a regular basis, and clarifying their experimental needs and expectations.
"No where do impediments to obtaining human eyes for research have more impact than in the effort to understand age-related macular degeneration, the leading cause of new vision loss in the elderly," said Curcio, a professor of ophthalmology at the University of Alabama at Birmingham. "Macular degeneration, an advanced form of which now has treatment options, still lacks a laboratory animal model that displays the full range of pathology typifying the human disorder. Thus, human tissues are particularly critical."
###
Read this article online at http://www.iovs.org/cgi/content/full/47/7/2747.
IOVS is published by the Association for Research in Vision and Ophthalmology (ARVO). For more information, logon to www.IOVS.org.
ARVO is a membership organization of more than 11,500 eye and vision researchers from over 70 countries. Established in 1928, the Association encourages and assists its members and others in research, training, publication and dissemination of knowledge in vision and ophthalmology. ARVO's headquarters are located in Rockville, Md. For more information about ARVO, logon to www.arvo.org. 认领“眼组织的短缺将危及未来的临床研究 ” 根据2006年7月《眼科及视觉科学研究》中的一篇文章报道，随着美国眼库提供的人类眼组织捐献数量的下降，未来眼科学的临床发展将受到严重的威胁。
根据美国ARVO组织成员的调查，影响人类眼组织使用的主要不利因素就是可应用的眼组织面临严重的缺乏。一位RTAWG的调查者，Christine A. Curcio发现调查中成本因素最为重要。被调查者也表示，虽然大多数调查者为了获得足够的研究所需的人类眼组织动用了多种眼组织来源，包括流动眼库，但是当地的眼库仍然是最普遍的眼组织来源。
过去十年间，联邦管控和每个州的法律严重影响了人类眼组织利用的研究，一些私人眼库在一定程度上起到了很重要的作用（如：法律禁止法医摘除由于暴力死亡或死因可疑患者的眼组织）。
RTAWG相信， 研究者可以与眼库或其他眼组织提供者密切合作，有序交流，阐明他们实验研究的需要和预期结果，这样人类研究组织的衰落会在短期内得到改善。
“毫无阻碍地获得人类科研所用的眼组织的影响要 比了解年龄相关的黄斑退行性改变－这个老年人视觉丧失的主要原因的影响更为深刻，”阿拉巴马州伯明翰大学眼科学教授Curcio说：“黄斑变性是由于年龄衰老产生的病变，目前有治疗方法，仍然缺乏能够最大限度的表现出人类典型病变病理过程的实验室动物模型的验证。因此，人类组织对于眼科学的发展至关重要。” 哇！糟了，没有认领就直接翻译了，请问楼主有效么？？ 搞不懂了，我认领了怎么别人也在翻译呀，管他呢，贴上去再说了。
眼组织的短缺将危及未来的临床研究
马里兰州，Rockvill市，——2006年7月《眼科研究与视觉科学》杂志（IOVS）上发表的一篇文章指出，因为美国的眼库提供捐献的眼组织不足也许将危及眼科临床的未来。
一项对美国“眼科与视觉研究学会”（ARVO）成员的调研表明，在使用人眼组织上最大的阻碍来自对人眼组织使用缺乏严格的执行标准。这项调研的指导者，来自 ARVO学会“研究用组织获得工作小组” (RTAWG)的 Christine A.Curcio, PhD指出，在这项调研中发现在阻碍人体组织用于研究的因素中只有高额的费用因素超过缺乏执行标准这个因素。调研的回复者们还指出虽然大多数研究者使用多种眼组织来源，甚至包括一些偏远的眼库，以获得充足的人眼组织用于科研，但是当地的眼库仍是他们最常用的组织来源。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-04-06 14:05
医学,生命科学网