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【bio-news】游离的侵入性细胞是癌症的基础
http://www.sciencedaily.com/releases/2008/12/081212222722.htm
ScienceDaily (Dec. 14, 2008) — Scientists at UCL funded by BBSRC and the Medical Research Council have discovered the mechanism by which cells normally repel each other – a process sidestepped by cancer cells which go on to invade and conquer healthy regions of the body.
The findings suggest an alternative way in which cancer treatments might work in the future, if therapies can be targeted at the process of ‘cell repulsion’ to stop cancer cells from spreading and causing secondary tumours.
Cells typically produce localized protrusions which help them navigate their environment. When two cells meet, they normally retract their protrusions and change their direction of movement, effectively ‘repelling’ one another. This phenomenon, called contact inhibition of locomotion, was first discovered 50 years ago in a UCL laboratory experiment, and its failure was thought to contribute to the malignant invasion of cancer. But it took up to now to witness the process in action and pin down the mechanism.
The latest UCL study led by Dr Roberto Mayor, UCL Cell and Developmental Biology, has captured the phenomenon ‘in vivo’ – in living tissue – and has identified the mechanism by which it works, suggesting possible new targets for future cancer therapies.
Dr Roberto Mayor says: "Contact inhibition of locomotion was first discovered by UCL Professor Michael Abercrombie more than 50 years ago, when he saw fibroblast cells under the microscope confront each other, retract their protrusions and change direction on contact. The failure of cells to repulse each other in this way was thought to play a role in the spread of cancer."
"However, until now the molecular basis of this process and whether it also occurred within the body was unknown. Our study of neural crest cells shows that these cells behave in exactly this way. When two migrating neural crest cells meet, they stop, collapse their protrusions and change direction. However, when a neural crest cell meets another cell type, it fails to behave as expected and instead invades the other tissue, in the same manner as metastatic cancer cells which migrate and go on to cause secondary tumours."
"Inhibition of a type of cell signalling - non-canonical Wnt signalling – is behind this behaviour, cancelling the normal repulsion you would expect between cells. Our discovery offers possible new targets for the future treatment of tumour metastasis – the spreading of cancer cells, one of the mostly deadly aspects of cancer."
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Journal reference:
Carmona-Fontaine et al. Contact inhibition of locomotion in vivo controls neural crest directional migration. Nature, 2008; DOI: 10.1038/nature07441
Adapted from materials provided by BBSRC. 认领此文编译，48小时未交稿，其他战友可自由认领。
望有全文的战友能奉献出来。。。。 Antisocial, Invasive Cells Are Basis Of Cancer, Finding Suggests
游离的侵入性细胞是癌症的基础
http://www.sciencedaily.com/releases/2008/12/081212222722.htm
UCL：University College London（伦敦大学学院）
BBSRC：Biotechnology and Biological Sciences Research Council（英国生物技术与生物科学研究委员会）
ScienceDaily (Dec. 14, 2008) — Scientists at UCL funded by BBSRC and the Medical Research Council have discovered the mechanism by which cells normally repel each other – a process sidestepped by cancer cells which go on to invade and conquer healthy regions of the body.
伦敦大学学院的科学家们（受英国生物技术与生物科学研究委员会和医学研究委员会资助）已经揭示了正常细胞间相互排斥的机制——而肿瘤细胞可以回避这种机制并继续侵犯和占领机体的健康组织。
The findings suggest an alternative way in which cancer treatments might work in the future, if therapies can be targeted at the process of ‘cell repulsion’ to stop cancer cells from spreading and causing secondary tumours.
本次发现也预示着一种新的，将来可能起作用的肿瘤治疗途径——如果能设计出针对“细胞排斥”过程的治疗即可阻止肿瘤细胞的扩散和远处转移。
Cells typically produce localized protrusions which help them navigate their environment. When two cells meet, they normally retract their protrusions and change their direction of movement, effectively ‘repelling’ one another. This phenomenon, called contact inhibition of locomotion, was first discovered 50 years ago in a UCL laboratory experiment, and its failure was thought to contribute to the malignant invasion of cancer. But it took up to now to witness the process in action and pin down the mechanism.
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作者:admin@医学,生命科学 2011-04-01 05:14
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