主页 > 生命科学 >
【medical-news】服药时禁喝果汁的新理由
Patients often are warned against taking certain pills with grapefruit juice, which can turn normal doses of a drug into a toxic overdose. Now, researchers have raised a new concern: grapefruit, orange and apple juices may also block the effects of some drugs, wiping out any potential benefit to patients, according to a new study.
Healthy volunteers took a dose of the allergy drug fexofenadine, downing it with water or juice. When the drug was taken with grapefruit juice, for instance, only half of the dose was absorbed into the bloodstream, compared to taking it with water. The findings were presented this week at the national meeting of the American Chemical Society by researchers at the University of Western Ontario in London, Ontario.
So far, the investigators have found that grapefruit, orange and apple juices reduce absorption of the anticancer drug etoposide; certain beta blockers used to treat high blood pressure; cyclosporine, used to prevent rejection of transplanted organs; and certain antibiotics. Additional drugs are likely to be added to the list, said David G. Bailey, a professor of clinical pharmacology at the University of Western Ontario.
“This is just the tip of the iceberg,” Dr. Bailey said. “I’m sure we’ll find more and more drugs that are affected this way.”
It was Dr. Bailey who originally identified the potential harm in consuming medications with grapefruit juice, showing that it can interact with drugs in a way that raises blood concentration of the medication to dangerous levels. It’s known to affect about 50 drugs, ranging from cholesterol-lowering statins to Viagra. Some drugs now carry labels warning consumers against taking them with grapefruit juice or fresh grapefruit.
Dr. Bailey said patients should consult with their doctors or pharmacists before taking any medications with grapefruit or other juices. The best advice, however, is to take most medications only with water.
http://well.blogs.nytimes.com/2008/08/20/new-reasons-to-avoid-mixing-juice-and-medicine/
screen.width-333)this.width=screen.width-333" width=190 height=238 title="Click to view full grapefruit_190.jpg (190 X 238)" border=0 align=absmiddle> 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 New Reasons to Avoid Mixing Juice and Medicine
服药时禁止喝果汁的新理由
Patients often are warned against taking certain pills with grapefruit juice, which can turn normal doses of a drug into a toxic overdose. Now, researchers have raised a new concern: grapefruit, orange and apple juices may also block the effects of some drugs, wiping out any potential benefit to patients, according to a new study.
患者在服用某些药物时，经常被警告不要与柚子汁一起服用，因为这样会使正常剂量的药物转变为过量的毒性剂量。现在，研究者又提出了新关注：据最新研究，柚子汁、橘子汁以及苹果汁还可能阻断某些药物的作用，消除其对患者的潜在益处。
Healthy volunteers took a dose of the allergy drug fexofenadine, downing it with water or juice. When the drug was taken with grapefruit juice, for instance, only half of the dose was absorbed into the bloodstream, compared to taking it with water. The findings were presented this week at the national meeting of the American Chemical Society by researchers at the University of Western Ontario in London, Ontario.
健康志愿者摄入一定量的过敏药物非索非那定（fexofenadine），他们分别以水或果汁服用。例如，与药物和水一起送服相比，果汁一起被摄入时，仅有一般剂量的药物被吸收入血。该发现由西安大略大学的研究者发表于本周召开的美国化学协会国家会议。
So far, the investigators have found that grapefruit, orange and apple juices reduce absorption of the anticancer drug etoposide; certain beta blockers used to treat high blood pressure; cyclosporine, used to prevent rejection of transplanted organs; and certain antibiotics. Additional drugs are likely to be added to the list, said David G. Bailey, a professor of clinical pharmacology at the University of Western Ontario.
至今，研究者发现柚子汁、橘子汁和苹果汁可以降低抗癌药物依托泊甙、某些用于治疗高血压的β受体阻滞剂、用于预防移植排异反应的环孢素以及某些抗生素的吸收。西安大略大学的临床药理学教授David G. Bailey说，很可能还有一些其他药物也受果汁的影响。
“This is just the tip of the iceberg,” Dr. Bailey said. “I’m sure we’ll find more and more drugs that are affected this way.”
It was Dr. Bailey who originally identified the potential harm in consuming medications with grapefruit juice, showing that it can interact with drugs in a way that raises blood concentration of the medication to dangerous levels. It’s known to affect about 50 drugs, ranging from cholesterol-lowering statins to Viagra. Some drugs now carry labels warning consumers against taking them with grapefruit juice or fresh grapefruit.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-13 17:14
医学,生命科学网