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【medical-news】复极检测能预测心梗后传导障碍者
23 January 2007
Unconventional measures of repolarization duration significantly and independently predict mortality in post-myocardial infarction (MI) patients with conduction disturbances, US researchers report.
They say that using Rautaharju-formula QTRR, QRS and JTRR intervals are preferable to the traditional QTc interval for evaluating repolarization duration in patients with ventricular conduction defects.
Noting that identification of abnormal repolarization and measurement of the QT interval is influenced by the presence of a wide QRS complex and bundle branch blocks, the team used Bazett QTc and JTc (QTc minus QRS) and Rautaharju QT and JTRR formulas to measure repolarization duration in 3282 patients who had recently suffered an MI.
In 259 patients with conduction disturbances, 126 (3.8%) had indeterminate ventricular conduction disturbances, 126 (3.8%) had right bundle branch block (RBB, and 47 (1.4%) had left bundle branch block (LBB.
Those with LBBB had an excessively prolonged QTc interval, which was not observed with the JTRR interval, the team reports in the American Journal of Cardiology.
To determine the prognostic significance of each repolarization parameter for predicting mortality, the researchers divided the patients into high- and low-risk groups, with high-risk defined as a repolarization duration >75th percentile for QTc, JTc, JTRR, and QTRR, QRS intervals.
Adjusted hazard ratios with each were 1.65 (p=0.062) for the QTc interval, 1.46 (0.168) for the JTc interval, 1.71 (p=0.043) for the QTRR, QRS interval, and 1.70 (p=0.044) for the JTRR interval.
"Our study indicates a substantial overestimation of repolarization duration in patients with LBBB when using a traditional QTc formula," write Wojciech Zareba and colleagues from University of Rochester, New York.
They conclude: "Patients with LBBB, RBBB, or indeterminate ventricular conduction disturbances show longer repolarization duration than patients without these conduction disturbances, and QTRR,QRS and JTRR intervals reflect better than QTc repolarization duration in patients with conduction disturbances."
Am J Cardiol 2007; 99: 163-168
http://www.incirculation.net/NewsItem/Repolarization-measures-predict-mortality-in-postM.aspx --------------------------------------------------------------------------------
本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Repolarization measures predict mortality in post-MI conduction disturbance patients
复极检测能预测心梗后传导障碍者的死亡率
23 January 2007
2007年1月23日
Unconventional measures of repolarization duration significantly and independently predict mortality in post-myocardial infarction (MI) patients with conduction disturbances, US researchers report.
美国研究者报道，复级持续时间的新型检测能显著独立地预测心梗后传导障碍者的死亡率．
They say that using Rautaharju-formula QTRR, QRS and JTRR intervals are preferable to the traditional QTc interval for evaluating repolarization duration in patients with ventricular conduction defects.
对心室传导缺陷的病人来说，与传统QTc间隔相比，使用Rautaharju方式的QTRR, QRS 和 JTRR间隔能更好地评估复级持续时间．
Noting that identification of abnormal repolarization and measurement of the QT interval is influenced by the presence of a wide QRS complex and bundle branch blocks, the team used Bazett QTc and JTc (QTc minus QRS) and Rautaharju QT and JTRR formulas to measure repolarization duration in 3282 patients who had recently suffered an MI.
因为注意到复极化异常和QT间隔的测量受到宽QRS波群和束支阻止的影响，在3282例最近有心梗的病人中，研究组使用Bazett QTc ， JTc (QTc minus QRS) ，Rautaharju QT 和 JTRR方式来测量复级持续时间．
In 259 patients with conduction disturbances, 126 (3.8%) had indeterminate ventricular conduction disturbances, 126 (3.8%) had right bundle branch block (RBB , and 47 (1.4%) had left bundle branch block (LBB .
在259例传导障碍患者中，136例（3.8％）有不定型传导阻滞，126（3.9％）有右束支传导阻滞，余下47例（1.4％）有左束支传导阻滞．
Those with LBBB had an excessively prolonged QTc interval, which was not observed with the JTRR interval, the team reports in the American Journal of Cardiology.
研究组在美国心脏病学杂志上报道：那些左束支传导阻滞者的QTc间隔很长，但是没有看到JTRR间隔异常．
To determine the prognostic significance of each repolarization parameter for predicting mortality, the researchers divided the patients into high- and low-risk groups, with high-risk defined as a repolarization duration >75th percentile for QTc, JTc, JTRR, and QTRR, QRS intervals.
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作者:admin@医学,生命科学 2011-09-01 05:12
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