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【medical-news】C-反应蛋白诱发高血压
Main Category: Hypertension News
Article Date: 22 Feb 2007 - 12:00 PST
C-Reactive Protein, widely regarded as a risk factor for hypertension and other forms of cardiovascular disease, plays a direct role in the onset of hypertension, researchers at UT Southwestern Medical Center have found.
"We have discovered that C-Reactive Protein (CRP) is not merely a marker of the risk of hypertension, it actually induces hypertension," said Dr. Wanpen Vongpatanasin, associate professor of internal medicine and lead author of the study appearing in the February issue of Circulation.
UT Southwestern researchers studied mice with an engineered gene for CRP that was under the regulation of a second gene responsive to changes in dietary carbohydrate intake. The levels of circulating CRP, which is produced by the liver, were directly manipulated by altering the mice's diets, and the effect on blood pressure was determined. In this manner the actions of CRP were segregated from the actions of other mediators of inflammation.
"We found that when we switched on the gene that causes increases in CRP, the blood pressure went up, and when we turned off the gene and CRP levels went down, the blood pressure fell. Diet changes in the control mice had no effect, indicating that the blood pressure responses were due to CRP," said Dr. Vongpatanasin. "The cause of elevated blood pressure induced by CRP was also determined."
Clinical studies over the past decade have suggested that chronically elevated levels of CRP indicate inflammation that puts an individual at risk for hypertension and other cardiovascular ailments such as hardening of the arteries.
The mice in the latest study were supersensitive to angiotensin II, which is a major circulating factor regulating blood pressure via arterial constriction. This was due to alterations in key proteins in the vascular wall that are involved with angiotensin II.
Also, the researchers discovered that the initiating mechanism is a lack of the key signaling molecule nitric oxide in the artery wall, which has multiple beneficial roles in the cardiovascular system, as well as made a connection between nitric oxide and the proteins responsible for angiotensin II activity.
"Whether these same processes are operative in humans is yet to be determined," said Dr. Vongpatanasin. "We are also pursuing follow-up studies to further understand better how CRP causes the high blood pressure in the mice."
The ultimate goal of the research is to discover how CRP interacts with molecules in the artery wall, leading to a better understanding of hypertension and pointing to new ways to treat it, Dr. Vongpatanasin said.
"We have uncovered a series of mechanisms that link a circulating factor that rises with chronic inflammation, obesity and aging to the regulation of blood pressure," said Dr. Philip Shaul, professor of pediatrics at UT Southwestern and the study's senior author. "Doing so provides a new perspective on how these conditions have a negative impact on cardiovascular health." 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 CRP Liver Protein Induces Hypertension
C-反应蛋白诱发高血压
Main Category: Hypertension News
Article Date: 22 Feb 2007 - 12:00 PST
消息分类：高血压消息
文章日期：2007年2月22日格林尼时间12：00
C-Reactive Protein, widely regarded as a risk factor for hypertension and other forms of cardiovascular disease, plays a direct role in the onset of hypertension, researchers at UT Southwestern Medical Center have found.
C-反应蛋白被广泛认为是诱发高血压和其它类型心血管疾病的一种危险因素，UT西南医学中心的研究者们发现它在高血压的诱发中扮演一个直接因素。
"We have discovered that C-Reactive Protein (CRP) is not merely a marker of the risk of hypertension, it actually induces hypertension," said Dr. Wanpen Vongpatanasin, associate professor of internal medicine and lead author of the study appearing in the February issue of Circulation.
内科学的副教授并且是出版在二月号《循环》杂志的这项研究的第一作者，Wanpen Vongpatanasin博士说：“我们已经发现C－反应蛋白（CRP）不仅仅是高血压的一种风险标记物，它还确实诱导高血压发生”。
UT Southwestern researchers studied mice with an engineered gene for CRP that was under the regulation of a second gene responsive to changes in dietary carbohydrate intake. The levels of circulating CRP, which is produced by the liver, were directly manipulated by altering the mice's diets, and the effect on blood pressure was determined. In this manner the actions of CRP were segregated from the actions of other mediators of inflammation.
UT西南医学中心的研究者们研究了转CRP基因的小鼠，这种小鼠的CRP可以通过规定的碳水化合物摄取来进行二级的基因调节。由肝脏产生的CRP水平可同归规定的人为的改变小鼠的饮食来调节，并且检测CRP对血压的影响。在这种方法中将CRP的活性同其它炎症介质的活性区分开。
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作者:admin@医学,生命科学 2011-07-14 11:18
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