主页 > 医药生命 >
【medical-news】MRI有助于早期诊断风湿性关节炎
NEW YORK (Reuters Health), Sep 27 - MRI of the hands can differentiate between patients with rheumatoid arthritis (RA) and patients with other diseases, even when x-rays are normal, symptoms are mild, and anticyclic citrullinated peptide (anti-CCP) antibodies are absent, researchers report in the September issue of the Journal of Rheumatology.
Early diagnosis of RA improves prognosis because treatment can be initiated before significant, irreversible damage occurs. But in the early stages, radiographs tend to be normal and anti-CCP antibodies may not yet be present.
In their prospective study, investigators at Lille University Hospital in France, led by Dr. Elisabeth Solau-Gervais, recruited 30 patients with polyarthritis with or without synovitis, with symptom onset no more that two years before. None had yet been treated with disease-modifying antirheumatic drugs, and patients had normal radiographs and no detectable levels of anti-CCP antibodies.
MR images of the hands and wrists were obtained to evaluate for synovitis and erosions.
According to the report, 16 patients were diagnosed with RA during the following year. The other patients were diagnosed with spondyloarthropathy, fibromyalgia, undifferentiated arthritis, sicca syndrome, hemochromatosis, polymyositis, or paraneoplastic syndrome.
The MRI images revealed significantly higher erosion scores for the metacarpophalangeal joint in RA patients than in the other group (19.3 versus 7.7), and for the second and third metacarpophalangeal joints (16.4 versus 5.7). MRI-detected erosions had a sensitivity of 64% and specificity of 70%.
Dr. Solau-Gervais and her associates conclude that when immunological markers and radiographs fail, "It is of interest to have another diagnosis tool such as MRI."
Last Updated: 2006-09-26 15:17:03 -0400 (Reuters Health)
J Rheumatol 2006;33:1760-1765. MRI helps diagnose early rheumatoid arthritis
NEW YORK (Reuters Health), Sep 27 - MRI of the hands can differentiate between patients with rheumatoid arthritis (RA) and patients with other diseases, even when x-rays are normal, symptoms are mild, and anticyclic citrullinated peptide (anti-CCP) antibodies are absent, researchers report in the September issue of the Journal of Rheumatology.
研究人员在9月份《风湿病》杂志中称：在X线阴性，症状轻微，没有C反应蛋白的时候，手MRI可以鉴别风湿性关节炎与其它病变。
Early diagnosis of RA improves prognosis because treatment can be initiated before significant, irreversible damage occurs. But in the early stages, radiographs tend to be normal and anti-CCP antibodies may not yet be present.
早期诊断风湿性关节炎有助于改善预后，因为可以造出现严重的不可逆病变之前进行早期治疗。但是在早期，x线检查阴性，抗c反应蛋白抗体检测不到。
In their prospective study, investigators at Lille University Hospital in France, led by Dr. Elisabeth Solau-Gervais, recruited 30 patients with polyarthritis with or without synovitis, with symptom onset no more that two years before. None had yet been treated with disease-modifying antirheumatic drugs, and patients had normal radiographs and no detectable levels of anti-CCP antibodies.
在法国利乐大学医院研究人员的前瞻性研究中，伊丽莎白博士小组研究了30例伴或者不伴滑膜炎的多关节炎，病史不到2年。都没有接受抗风湿治疗，病人x线检查正常，c反应蛋白测试阴性。
MR images of the hands and wrists were obtained to evaluate for synovitis and erosions.
通过MRI的手部和腕部成像评价滑膜炎和骨侵蚀。
According to the report, 16 patients were diagnosed with RA during the following year. The other patients were diagnosed with spondyloarthropathy, fibromyalgia, undifferentiated arthritis, sicca syndrome, hemochromatosis, polymyositis, or paraneoplastic syndrome.
根据本研究，16例病人在随访的一年内诊断风湿性关节炎。其它病人诊断为脊柱关节紊乱、纤维肌痛、未分化性骨炎、干燥综合征，血色素沉着病，多发性肌炎、副肿瘤综合征。
The MRI images revealed significantly higher erosion scores for the metacarpophalangeal joint in RA patients than in the other group (19.3 versus 7.7), and for the second and third metacarpophalangeal joints (16.4 versus 5.7). MRI-detected erosions had a sensitivity of 64% and specificity of 70%.
与其它病人相比，风湿性关节炎病人的掌指骨关节面明显侵蚀，MRI发现的这种关节面破坏对于对于风湿性关节炎的诊断敏感性为64%，特异性为70%。
Dr. Solau-Gervais and her associates conclude that when immunological markers and radiographs fail, "It is of interest to have another diagnosis tool such as MRI."
Solau－Gervais研究小组结论为：如果免疫标记物及放射学检查阴性，进行其它检查，例如MRI进行诊断是非常有意义的。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-07-04 11:55
医学,生命科学网