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sars病毒主要蛋白及其抑制引子的晶体结构The cr
摘要：
A newly identified severe acute respiratory syndrome coronavirus (SARS-CoV), is the etiological agent responsible for the outbreak of SARS. The SARS-CoV main protease, which is a 33.8-kDa protease (also called the 3C-like protease), plays a pivotal role in mediating viral replication and transcription functions through extensive proteolytic processing of two replicase polyproteins, pp1a (486 kDa) and pp1ab (790 kDa). Here, we report the crystal structures of the SARS-CoV main protease at different pH values and in complex with a specific inhibitor. The protease structure has a fold that can be described as an augmented serine-protease, but with a Cys-His at the active site. This series of crystal structures, which is the first, to our knowledge, of any protein from the SARS virus, reveal substantial pH-dependent conformational changes, and an unexpected mode of inhibitor binding, providing a structural basis for rational drug design.
关键词：SARS, severe acute respiratory syndrome; CoV, coronavirus; HcoV, human CoV; Mpro, main protease; TGEV, porcine transmissible gas
全文链接：
http://www.pnas.org/cgi/content/full/100/23/13190 It's really a significant work! [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-09-02 17:15
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