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【Nat Rev Cancer】Paul Ehrlich 魔术弹概念：抗癌百年
Exceptional advances in molecular biology and genetic research have expedited cancer drug development tremendously. The declared paradigm is the development of 'personalized and tailored drugs' that precisely target the specific molecular defects of a cancer patient. It is therefore appropriate to revisit the intellectual foundations of the development of such agents, as many have shown great clinical success. One hundred years ago, Paul Ehrlich, the founder of chemotherapy, received the Nobel Prize for Physiology or Medicine. His postulate of creating 'magic bullets' for use in the fight against human diseases inspired generations of scientists to devise powerful molecular cancer therapeutics.
http://www.nature.com/nrc/journal/v8/n6/abs/nrc2394.html 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Paul Ehrlich's magic bullet concept: 100 years of progress
Exceptional advances in molecular biology and genetic research have expedited cancer drug development tremendously. The declared paradigm is the development of 'personalized and tailored drugs' that precisely target the specific molecular defects of a cancer patient. It is therefore appropriate to revisit the intellectual foundations of the development of such agents, as many have shown great clinical success. One hundred years ago, Paul Ehrlich, the founder of chemotherapy, received the Nobel Prize for Physiology or Medicine. His postulate of creating 'magic bullets' for use in the fight against human diseases inspired generations of scientists to devise powerful molecular cancer therapeutics.
保罗 埃尔利希的魔术弹概念：百年进展
在分子生物学和基因研究方面得巨大进步极大地加快抗癌药物发展。“个性化和定向药物”正发展成为治疗的规范，这些药物针对一个具体癌症病人的分子缺陷。由于这些药物表现出极大的临床成功，因此这是适当的时候来回顾这些药物发展的智慧基石。一百年前，保罗 埃尔利希，化疗的创始人，获得了诺贝尔奖生理学和医学奖。他定义的'魔术子弹' 概念鼓舞一代又一代的科学家在对抗人类疾病的方面寻找强而有力的分子癌症治疗方法。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-08-31 05:19
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