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【medical-news】一些男性可能前列腺癌误诊
Prostate cancer misdiagnosed in some men
Overweight men are far more likely to get misleading results to prostate cancer tests that compromise their treatment, new research has revealed.
A study has found that prostate biopsies commonly used to diagnose the extent of the disease regularly underestimate the severity in men carrying extra weight.
The results, published by US scientists on Wednesday, suggest that many men receive inadequate or inappropriate treatment that is not aggressive enough to combat the true nature of their disease.
Cancer Council Australia chief executive, professor Ian Olver, said the findings were concerning, and urged clinicians to carry out more thorough testing on these patients.
The study compared biopsy results with actual disease in more than 1,100 US men who had had their prostate removed as part of their cancer treatment.
A biopsy - surgery to remove and test small slices of the organ - typically follows the standard PSA blood test used to indicate the presence of disease.
The research, led by Duke University, showed that obese men were 89 per cent more likely than slim men to have a more aggressive form of prostate cancer than was indicated by biopsy.
Men who registered as overweight but not obese had a 44 per cent increased risk.
Study leader Stephen Freedland said the results were worrying because under-diagnosed men potentially miss out on additional treatment, like hormone therapy, that could save lives.
It was already known that PSA test readings were less accurate in overweight men, he said.
"These findings further suggest that we could be missing even more high-grade disease among obese men," Dr Freeland wrote in the latest issue of the journal Urology.
The reason for the discrepancy was still unclear. But the researchers believe obese men's larger prostates could mean that the usual number of samples taken during a biopsy is insufficient to reveal the gland's actual status.
Prof Olver said it was important clinicians were aware of the problem and conducted more biopsies on these patients to get a more accurate result.
"It also underlines the fact that we need better ways to diagnose and predict the outcome for this disease," Prof Olver said. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 http://www.smh.com.au/news/National/Prostate-cancer-misdiagnosed-in-some-men/2007/03/28/1174761509361.html
Prostate cancer misdiagnosed in some men
一些男性的前列腺癌被误诊
Overweight men are far more likely to get misleading results to prostate cancer tests that compromise their treatment, new research has revealed.
肥胖的男性在前列腺癌试验中更容易得到一个错误的结果从而影响他们的治疗，一项新的研究表明。
A study has found that prostate biopsies commonly used to diagnose the extent of the disease regularly underestimate the severity in men carrying extra weight.
这项研究发现通常被用于诊断前列腺癌病情的前列腺活检经常低估了超重男性的严重程度，
The results, published by US scientists on Wednesday, suggest that many men receive inadequate or inappropriate treatment that is not aggressive enough to combat the true nature of their disease.
美国科学家周三公布的这个结果表明许多男性接受了不充分或不合适的治疗，因为这些治疗不足以与疾病的实质相抗争。
Cancer Council Australia chief executive, professor Ian Olver, said the findings were concerning, and urged clinicians to carry out more thorough testing on these patients.
澳大利亚癌症委员会首席执行官Ian Olver教授说这项发现是令人瞩目的，他还要求临床学家们为这些病人提供更彻底的检查手段。
The study compared biopsy results with actual disease in more than 1,100 US men who had had their prostate removed as part of their cancer treatment.
超过1100位患有前列腺癌的美国男性切除了他们的前列腺作为治疗的一部分，然后这项研究就把活检结果同实际病情相比较。
A biopsy - surgery to remove and test small slices of the organ - typically follows the standard PSA blood test used to indicate the presence of disease.
通常为了指出这种疾病是否存在，我们要进行血PSA检测，然后才会进行活检即手术切除后观察器官的断层薄片。
The research, led by Duke University, showed that obese men were 89 per cent more likely than slim men to have a more aggressive form of prostate cancer than was indicated by biopsy.
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作者:admin@医学,生命科学 2011-08-29 17:12
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