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【medical-news】急性心梗后心脏收缩同步化重塑的
Heart 2008;94:995-1001
ABSTRACT
Objective: To evaluate the effects of stem cell therapy on restoration of the left ventricular (LV) synchronous contraction in patients with acute myocardial infarction (AMI).
Methods: 40 patients with AMI who underwent successful coronary revascularisation were randomly allocated to the cell infusion or the control group. Evaluations were performed with echocardiographic tissue synchronisation imaging to determine LV dyssynchrony and with cardiac magnetic resonance imaging to estimate LV ejection fraction (LVEF) at baseline and at 6 months. To quantify the severity of systolic LV dyssynchrony, the standard deviations of time to peak systolic velocity of the 12 LV segments (Ts-SD) were calculated.
Results: At 6 months, greater improvements of Ts-SD (Ts-SD: –45.0 (40.2) vs 5.0 (39.9) ms, p<0.001) and LVEF (LVEF: 6.8% (9.1%) vs –0.2% (6.9%), p = 0.015) relative to the corresponding baseline values were observed in the cell infusion group than in the control group. By multivariate analysis, Ts-SD and baseline LVEF emerged as the independent determinants of LVEF improvement and cell infusion, and baseline Ts-SD as the determinant of Ts-SD improvement. Maximal exercise capacity measured by symptom-limited treadmill testing correlated well with Ts-SD but not with LVEF at 6 months of follow-up.
Conclusion: Stem cell therapy had a favourable effect on the restoration of LV synchronous contraction in patients with AMI. Restoration of left ventricular synchronous contraction after acute myocardial infarction by stem cell therapy: new insights into the therapeutic implication of stem cell therapy for acute myocardial infarction
干细胞治疗恢复急性心肌梗死后患者左心同步化收缩：干细胞治疗急性心肌梗死治疗意义新视角
ABSTRACT
Objective: To evaluate the effects of stem cell therapy on restoration of the left ventricular (LV) synchronous contraction in patients with acute myocardial infarction (AMI).
目的：评价干细胞治疗恢复急性心肌梗死患者左心室同步收缩的作用。
Methods: 40 patients with AMI who underwent successful coronary revascularisation were randomly allocated to the cell infusion or the control group. Evaluations were performed with echocardiographic tissue synchronisation imaging to determine LV dyssynchrony and with cardiac magnetic resonance imaging to estimate LV ejection fraction (LVEF) at baseline and at 6 months. To quantify the severity of systolic LV dyssynchrony, the standard deviations of time to peak systolic velocity of the 12 LV segments (Ts-SD) were calculated.
方法：40例接受了成功的冠脉再血管化的急性心肌梗死患者随机分配为干细胞注射组或对照组。采用心脏超声组织同步化显像评价基线和6月后左心室失同步化，采用心脏磁共振显像评价基线和6月后左心室射血分数。采用左心室12个部位峰值收缩速度时间的标准差（Ts-SD）量化左心室收缩失同步。
Results: At 6 months, greater improvements of Ts-SD (Ts-SD: –45.0 (40.2) vs 5.0 (39.9) ms, p<0.001) and LVEF (LVEF: 6.8% (9.1%) vs –0.2% (6.9%), p = 0.015) relative to the corresponding baseline values were observed in the cell infusion group than in the control group. By multivariate analysis, Ts-SD and baseline LVEF emerged as the independent determinants of LVEF improvement and cell infusion, and baseline Ts-SD as the determinant of Ts-SD improvement. Maximal exercise capacity measured by symptom-limited treadmill testing correlated well with Ts-SD but not with LVEF at 6 months of follow-up.
结果：与对照组相比，干细胞注射组6月后的Ts-SD（Ts-SD: –45.0 (40.2) vs 5.0 (39.9) ms, p<0.001）和左心室射血分数（LVEF: 6.8% (9.1%) vs –0.2% (6.9%), p = 0.015）较基线时显著改善。在多因素分析中，Ts-SD和基线时LVEF是LVEF改善的独立决定因子，干细胞注射和基线Ts-SD是Ts-SD改善的决定因子。随访6月后，采用症状限制的平板运动试验测得的最大运动耐量与Ts-SD相关，而与LVEF无关。
Conclusion: Stem cell therapy had a favourable effect on the restoration of LV synchronous contraction in patients with AMI.
结论：干细胞治疗对恢复急性心肌梗死患者左心室同步收缩有良好的作用。
干细胞治疗恢复急性心肌梗死后患者左心同步化收缩：干细胞治疗急性心肌梗死治疗意义新视角
目的：评价干细胞治疗恢复急性心肌梗死患者左心室同步收缩的作用。
方法：40例接受了成功的冠脉再血管化的急性心肌梗死患者随机分配为干细胞注射组或对照组。采用心脏超声组织同步化显像评价基线和6月后左心室失同步化，采用心脏磁共振显像评价基线和6月后左心室射血分数。采用左心室12个部位峰值收缩速度时间的标准差（Ts-SD）量化左心室收缩失同步。
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作者:admin@医学,生命科学 2011-08-29 05:14
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