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【文摘发布】实时三维超声心动图揭示左房Fran
Ashraf M Anwar1, Marcel L Geleijnse2, Osama I I Soliman1,2, Attila Nemes2, Folkert J ten Cate2
1 Cardiology Department, Al-Husein University Hospital, Al-Azhar University, Cairo, Egypt
2 Thoraxcentre, Erasmus MC, Rotterdam, The Netherlands
ABSTRACT
Background: The Frank–Starling law describes the relation between left ventricular volume and function. However, only a few studies have described the relation between left atrial volume (LAV) and function.
Objective: To describe an LA Frank–Starling law by studying changes in LAV measured by real-time, three-dimensional echocardiography (RT3DE).
Methods: LAV was calculated by RT3DE in 70 patients at end-systole (LAVmax), end-diastole (LAVmin) and pre-atrial contraction (LAVpre-A). According to LAVmax, patients were classified into three groups: LAVmax <50 ml (group I), LAVmax 50–70 ml (group II) and LAVmax >70 ml (group III). Calculated indices of LA pump function were active atrial stroke volume (SV), defined as LAVpre-A – LAVmin, and active atrial emptying fraction (EF), defined as active atrial SV/LAVpre-A x100%
Results: Active atrial SV was significantly higher in group II than in group I (mean (SD) 19.0 (9.2) vs 8.2 (4.9) ml, p<0.0001), in group III it was non-significantly lower than in group II (16.7 (12.5) vs 19.0 (9.2) ml). Active atrial SV correlated well with LAVpre-A (r = 0.56, p<0.001), but decreased with larger LAVpre-A. Active atrial EF tended to be higher in group II than in group I (43.1 (18.2) vs 33.2 (17.5), p<0.10), in group III it was significantly lower than in group II (26.2 (18.5) vs 43.1 (18.2), p<0.01).
Conclusion: A Frank–Starling mechanism in the left atrium could be described by RT3DE, shown by an increase in LA contractility in response to an increase in LA preload up to a point, beyond which LA contractility decreased.
Heart 2007;93:1393-1397 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Left atrial Frank–Starling law assessed by real-time, three-dimensional echocardiographic left atrial volume changes
实时三维超声心动图的左房容积变化评估左房Frank–Starling定律
ABSTRACT
Background: The Frank–Starling law describes the relation between left ventricular volume and function. However, only a few studies have described the relation between left atrial volume (LAV) and function.
背景：Frank–Starling定律描述了左室容积和功能的关系，但是，很少有研究描述左房容积（LAV）和功能之间的关系。
Objective: To describe an LA Frank–Starling law by studying changes in LAV measured by real-time, three-dimensional echocardiography (RT3DE).
目的：通过实时三维超声心动图(RT3DE)观察LAV变化来描述左房（LA） Frank–Starling定律。
Methods: LAV was calculated by RT3DE in 70 patients at end-systole (LAVmax), end-diastole (LAVmin) and pre-atrial contraction (LAVpre-A). According to LAVmax, patients were classified into three groups: LAVmax <50 ml (group I), LAVmax 50–70 ml (group II) and LAVmax >70 ml (group III). Calculated indices of LA pump function were active atrial stroke volume (SV), defined as LAVpre-A –LAVmin, and active atrial emptying fraction (EF), defined as active atrial SV/LAVpre-A x100%
方法：选取70例患者，采用RT3DE分别测量收缩末期LAV (LAVmax), 舒张末期LAV (LAVmin)和心房收缩前LAV (LAVpre-A)。根据LAVmax将患者分为三组：LAVmax <50 ml (组 I), LAVmax 50–70 ml (组II) 和 LAVmax >70 ml (组III)。计算出LA泵功能指数，LAVpre-A –LAVmin为心房主动搏出量（SV），心房主动SV/LAVpre-A x100%为心房主动排空指数（EF）。
Results: Active atrial SV was significantly higher in group II than in group I (mean (SD) 19.0 (9.2) vs 8.2 (4.9) ml, p<0.0001), in group III it was non-significantly lower than in group II (16.7 (12.5) vs 19.0 (9.2) ml). Active atrial SV correlated well with LAVpre-A (r = 0.56, p<0.001), but decreased with larger LAVpre-A. Active atrial EF tended to be higher in group II than in group I (43.1 (18.2) vs 33.2 (17.5), p<0.10), in group III it was significantly lower than in group II (26.2 (18.5) vs 43.1 (18.2), p<0.01).
结果：组II 的SV 显著高于组 I [均数(标准差) 19.0 (9.2) vs 8.2 (4.9) ml, p<0.0001],组III的SV低于组II，但无统计学意义[16.7 (12.5) vs 19.0 (9.2) ml]。心房主动SV 与 LAVpre-A具有良好的相关性 (r = 0.56, p<0.001), 但是 LAVpre-A进一步增加，心房主动SV反而下降。组II的心房主动EF有高于组 I的趋势 [43.1 (18.2) vs 33.2 (17.5), p<0.10], 组III的心房主动EF显著低于组II [26.2 (18.5) vs 43.1 (18.2), p<0.01]。
Conclusion: A Frank–Starling mechanism in the left atrium could be described by RT3DE, shown by an increase in LA contractility in response to an increase in LA preload up to a point, beyond which LA contractility decreased.
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作者:admin@医学,生命科学 2011-05-08 17:11
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