主页 > 医药科学 >
【medical-news】[翻译]肠内蛋白可能有助于治病(I
Intestinal Protein May Help Fight Disease
THURSDAY, Aug. 24 (HealthDay News) -- U.S. researchers have discovered an intestinal protein that defends the organ against microbial invaders.
The finding offers new insight into how the intestine fights off pathogens, says a team from the University of Texas Southwestern Medical Center, and could lead to treatments for inflammatory bowel disease and intestinal infections.
"We found that when the gut lining comes into contact with bacteria, it produces a protein that binds to sugars that are part of the bacterial outer surface. Once bound, these proteins quickly destroy their bacterial targets. They're killer proteins with a sweet tooth," study senior author Dr. Lora Hooper, assistant professor of immunology, said in a prepared statement.
The researchers used mice raised inside plastic sterile bubbles. Because the mice had never been in contact with microbes in the outside world, they did not have the bacteria that normally colonize the gut.
During the study, the mice were exposed to different types of gut bacteria and the researchers observed how the epithelial cells lining the rodents' intestines responded to these invaders.
This protein is called RegIIIgamma in mice and HIP/PAP in humans. The protein may help create an "electric fence" that protects the intestinal surface against invading bacteria, Hooper explained.
The study appears in the Aug. 25 issue of Science.
People with inflammatory bowel disease, which can cause painful ulcers and bloody diarrhea, have elevated levels of HIP/PAP production.
-- Robert Preidt
SOURCE: University of Texas Southwestern Medical Center, news release, Aug. 24, 2006
Copyright ?2006 ScoutNews LLC. All rights reserved. http://www.medicinenet.com/script/main/art.asp?articlekey=63712
肠内蛋白可能有助于治病
THURSDAY, Aug. 24 (HealthDay News)—美国研究者发现一种肠内蛋白会帮助器官抵御微生物的侵袭.
这个发现提供了关于肠子抵抗病原体机制新看法, 德州大学西南医学中心的研究组说, 这可能会有助于找到治疗肠类疾病发炎症状的新方法.
“我们发现, 当肠子内壁细胞碰到细菌时, 就会制造一种蛋白质. 这种蛋白质会结合到细菌外表面的糖结构上. 一旦结合, 这些蛋白质会很快的消灭这些细菌. 他们就是有甜蜜牙齿的杀手蛋白,” 免疫助理教授Lora Hooper博士说.
研究者使用的是饲养在无菌的塑料泡里面老鼠. 因为这些老鼠从来没有接触过外界微生物, 他们的肠子里面没有细菌.
在研究过程中, 老鼠暴露于不同的肠内细菌, 研究者观察肠内上皮细胞是如何应付这些入侵者的.
这种蛋白质在老鼠里面叫RegIIIgamma, 人体里面就是 HIP/PAP. 这种蛋白有助于形成一道”电子防御墙”, 抵御入侵病菌, 保卫肠表面, Hooper解释说.
这项研究发表于8月Science杂志上.
肠内有炎症的人会得疼痛的溃疡以及腹泻出血, 他们肠内HIP/PAP的产量会有提高.
-- Robert Preidt
SOURCE: University of Texas Southwestern Medical Center, news release, Aug. 24, 2006
Copyright ?2006 ScoutNews LLC. All rights reserved. [标签:content1][标签:content2]
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-17 05:14
医学,生命科学网